EM Tomography of Meiotic LINC Complexes.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8691-0_1
Abstract: Electron microscope (EM) tomography is a powerful technique that enables the three-dimensional analysis of subcellular structures at high resolution. We have applied this method to the quantitative analysis of LINC complex distribution and interaction with… read more here.
Keywords: meiotic linc; linc complexes; biology; tomography meiotic ... See more keywords
LINC complexes as regulators of meiosis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.01.005
Abstract: Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in… read more here.
Keywords: linc complexes; complexes regulators; homologous chromosomes; regulators meiosis ... See more keywords
Linc-FOXD3 knockdown enhances hippocampal NSCs activation through upregulation of the Wnt/β-catenin pathway
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134991
Abstract: Hippocampal neural stem cells (H-NSCs) self-renewal and neurogenesis decrease with aging, but the intrinsic mechanism is unclear. In the current study, we detected the expression level of 8 conserved long intergenic noncoding RNAs (lincRNAs) in… read more here.
Keywords: catenin pathway; linc foxd3; foxd3 knockdown; wnt catenin ... See more keywords
Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-06-0467
Abstract: Different forms of nuclear envelope–spanning LINC complexes have opposing roles in the transcription-independent control of the small GTPase RhoA. Competition between LINC complexes in the nuclear envelope may therefore dictate the outcome of signaling to… read more here.
Keywords: linc complexes; opposing roles; gtpase rhoa; small gtpase ... See more keywords
The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370219876651
Abstract: Three major proteins in the nucleoskeleton, lamins, actin, and spectrin, play essential roles in maintenance of nuclear architecture and the integrity of the nuclear envelope, in mechanotransduction and mechanical coupling between the nucleoskeleton and cytoskeleton,… read more here.
Keywords: dna repair; lamins actin; spectrin; linc ... See more keywords
Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0197621
Abstract: LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements. Most human cells contain two SUN proteins, Sun1 and… read more here.
Keywords: linc complexes; domain proteins; linc; gene expression ... See more keywords
Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202302031
Abstract: The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases. We provide evidence for SUN2 disulfide bond rearrangement as a physiologically relevant structural modification… read more here.
Keywords: disulfide bond; sun2 regulates; linc; bond sun2 ... See more keywords
The Role of the LINC Complex in Sperm Development and Function
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21239058
Abstract: The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located… read more here.
Keywords: linc complex; complex sperm; role linc; development ... See more keywords