An alternative σ factor σLsl regulates lincomycin production in Streptomyces lincolnensis
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DOI: 10.1002/jobm.202200485
Abstract: Lincomycin produced by Streptomyces lincolnensis is a critical antibacterial antibiotic in the clinical. To further understand the regulatory mechanism of lincomycin biosynthesis, we identified an alternative σ factor, σLsl, in Streptomyces lincolnensis NRRL 2936. Deletion… read more here.
Keywords: factor lsl; lsl; lincomycin production; alternative factor ... See more keywords
Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis
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DOI: 10.1186/s12934-020-01298-0
Abstract: Background Lincomycin, produced by Streptomyces lincolnensis , is a lincosamide antibiotic and widely used for the treatment of the infective diseases caused by Gram-positive bacteria. The mechanisms of lincomycin biosynthesis have been deeply explored in… read more here.
Keywords: regulatory effects; biosynthesis; effects lmbu; comparative transcriptomic ... See more keywords