Sustained Remission Without Corticosteroids Among Patients With Pemphigus Who Had Rituximab as First-Line Therapy: Follow-Up of the Ritux 3 Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.5679
Abstract: Importance The Ritux 3 trial demonstrated the short-term efficacy and safety of first-line treatment with rituximab compared with a standard corticosteroid regimen in pemphigus. No data on the long-term follow-up of patients who received rituximab… read more here.
Keywords: ritux trial; group; first line; line ... See more keywords
Use of First-Line Immune Checkpoint Inhibitors and Association With Overall Survival Among Patients With Metastatic Melanoma in the Anti–PD-1 Era
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.25459
Abstract: Key Points Question Following the US Food and Drug Administration’s approval of PD-1 immune checkpoint inhibitors (ICI) for metastatic melanoma, what were the utilization and overall survival associated with ICI in the first-line setting after… read more here.
Keywords: first line; overall survival; line; metastatic melanoma ... See more keywords
Effect of a MUC5AC Antibody (NPC-1C) Administered With Second-Line Gemcitabine and Nab-Paclitaxel on the Survival of Patients With Advanced Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.49720
Abstract: Key Points Question Does targeting MUC5AC with the NPC-1C antibody augment the antitumor activity of gemcitabine plus nab-paclitaxel as a second-line treatment for pancreatic cancer? Findings In this randomized phase 2 trial of 78 patients… read more here.
Keywords: nab paclitaxel; advanced pancreatic; line; line gemcitabine ... See more keywords
Therapy Attrition and Lessons for Future Approaches to Treatment of Advanced Urothelial Cancer.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2024.9426
Abstract: Metastatic or advanced urothelial cancer (aUC) is an aggressive disease, and many patients with this malignant neoplasm do not survive past their first line of therapy. The study by Thomas et al 1 is important… read more here.
Keywords: oncology; treatment; urothelial cancer; first line ... See more keywords
Association of Immune-Related Adverse Event Management With Survival in Patients With Advanced Melanoma.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.5041
Abstract: Importance Management of checkpoint inhibitor-induced immune-related adverse events (irAEs) is primarily based on expert opinion. Recent studies have suggested detrimental effects of anti-tumor necrosis factor on checkpoint-inhibitor efficacy. Objective To determine the association of toxic… read more here.
Keywords: advanced melanoma; patients advanced; management; line ... See more keywords
Nivolumab + Ipilimumab as Immunotherapeutic Boost in Metastatic Urothelial Carcinoma: A Nonrandomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.0938
Abstract: Importance Studies with nivolumab, an approved therapy for metastatic urothelial carcinoma (mUC) after platinum-based chemotherapy, demonstrate improved outcomes with added high-dose ipilimumab. Objective To assess efficacy and safety of a tailored approach using nivolumab + ipilimumab as… read more here.
Keywords: cohort; line cohort; second third; first line ... See more keywords
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA surgery"
DOI: 10.1001/jamasurg.2020.2286
Abstract: Importance Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (GA) are first-line chemotherapy regimens for pancreatic cancer. Their relative efficacy in the setting of localized disease is unknown. Objective To evaluate… read more here.
Keywords: response; line; first line; folfirinox ... See more keywords
SOX‐11 regulates LINE‐1 retrotransposon activity during neuronal differentiation
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13260
Abstract: Activity of the human long interspersed nuclear elements‐1 (LINE‐1) retrotransposon occurs mainly in early embryonic development and during hippocampal neurogenesis. SOX‐11, a transcription factor relevant to neuronal development, has unknown functions in the control of… read more here.
Keywords: line retrotransposon; activity; neuronal differentiation; line ... See more keywords
Electron dynamics surrounding the X line in asymmetric magnetic reconnection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Geophysical Research"
DOI: 10.1002/2017ja023969
Abstract: Electron dynamics surrounding the X-line in magnetopause-type asymmetric reconnection is investigated using a two-dimensional particle-in-cell simulation. We study electron properties of three characteristic regions in the vicinity of the X-line. The fluid properties, velocity distribution… read more here.
Keywords: electron dynamics; line; dynamics surrounding; electron ... See more keywords
Study of a Line‐Patterning Process Using Impact Print‐Type Hot Embossing Technology
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Engineering Materials"
DOI: 10.1002/adem.201901011
Abstract: An impact print‐type hot embossing process is a method for creating arbitrary patterns on polymer film in real‐time. This process can form 20–100 μm dot patterns and line patterns using an impact head and a high‐precision… read more here.
Keywords: hot embossing; film; print type; line ... See more keywords
Can Reconstructed Se-Deficient Line Defects in Monolayer VSe2 Induce Magnetism?
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202000693
Abstract: There have been several recent conflicting reports on the ferromagnetism of clean monolayer VSe2 . Herein, the controllable formation of 1D defect line patterns in vanadium diselenide (VSe2 ) monolayers initiated by thermal annealing is… read more here.
Keywords: reconstructed deficient; line; microscopy; monolayer vse2 ... See more keywords