Methylation of LINE-1 and Alu repetitive sequence in keloid
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DOI: 10.1038/s41598-025-17646-2
Abstract: Keloid is a trauma-induced fibroproliferative condition characterized by excessive extracellular matrix (ECM) deposition and aberrant keloid fibroblast activation, leading to physical, psychological, functional, and cosmetic impairments. This study investigates DNA methylation alterations at Long Interspersed… read more here.
Keywords: methylation; methylation levels; line alu; line ... See more keywords
An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers
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DOI: 10.1371/journal.pone.0316394
Abstract: The autonomous and active Long-Interspersed Element-1 (LINE-1, L1) and the non-autonomous Alu retrotransposon elements, contributing to 30% of the human genome, are the most abundant repeated sequences. With more than 90% of their sequences being… read more here.
Keywords: hypermethylation; cell free; circulating cell; line alu ... See more keywords