Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan
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DOI: 10.1001/jamanetworkopen.2021.45515
Abstract: Key Points Question What are the comparative short-term and long-term outcomes associated with first-line chemotherapy regimens for patients with metastatic pancreatic cancer, and how do they compare with chemotherapy regimens recommended in Japanese guidelines? Findings… read more here.
Keywords: metastatic pancreatic; pancreatic cancer; first line; line chemotherapy ... See more keywords
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
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DOI: 10.1001/jamasurg.2020.2286
Abstract: Importance Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (GA) are first-line chemotherapy regimens for pancreatic cancer. Their relative efficacy in the setting of localized disease is unknown. Objective To evaluate… read more here.
Keywords: response; line; first line; folfirinox ... See more keywords
Relationship of circulating tumor cells and Epstein–Barr virus DNA to progression‐free survival and overall survival in metastatic nasopharyngeal carcinoma patients
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DOI: 10.1002/ijc.32380
Abstract: We analyzed the number of circulating tumor cells (CTCs) and Epstein–Barr virus DNA (EBV DNA) for diagnosis, monitoring and prognosis of patients with metastatic nasopharyngeal carcinoma (mNPC). The levels of CTCs and EBV DNA were… read more here.
Keywords: dna; first line; ctcs ebv; ebv dna ... See more keywords
Reduction of derived neutrophil-to-lymphocyte ratio after four weeks predicts the outcome of patients receiving second-line chemotherapy for metastatic colorectal cancer
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DOI: 10.1007/s00262-020-02761-y
Abstract: Systemic inflammation response (SIR) plays a role in predicting prognosis of patients with metastatic colorectal cancer (mCRC). Chemotherapy-induced neutropenia has been suggested as another evaluable prognostic and predictive factor. This is a retrospective analysis of… read more here.
Keywords: chemotherapy; reduction; line; cancer ... See more keywords
Perioperative second-line chemotherapy is beneficial for resectable liver metastases that occur during or early after adjuvant chemotherapy for colorectal cancer
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DOI: 10.1007/s00384-022-04111-z
Abstract: The prognosis of patients with liver metastases during or early after adjuvant chemotherapy for colorectal cancer (CRC) is significantly worse. This study aimed to explore the efficacy of perioperative second-line chemotherapy in prolonging survival in… read more here.
Keywords: second line; chemotherapy; liver metastases; perioperative second ... See more keywords
Impact of omitting fluorouracil from FOLFIRI plus bevacizumab as second-line chemotherapy for patients with metastatic colorectal cancer
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DOI: 10.1007/s00432-022-03979-2
Abstract: Fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab is the standard second-line chemotherapy for patients with metastatic colorectal cancer (mCRC) who are refractory or intolerant to fluoropyrimidines and oxaliplatin. However, the benefits of incorporating fluoropyrimidines into… read more here.
Keywords: line chemotherapy; second line; folfiri plus; plus bevacizumab ... See more keywords
Second-line chemotherapy for patients with advanced gastric cancer
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DOI: 10.1007/s10120-017-0707-8
Abstract: The first choice for treating patients with metastatic gastric cancer is chemotherapy, and combination therapy with fluorouracil, platinum, and trastuzumab has been established as the standard first-line chemotherapy. For further improvement of treatment outcomes, it… read more here.
Keywords: gastric cancer; line chemotherapy; second line; line ... See more keywords
Associations between early tumor shrinkage and depth of response and clinical outcomes in patients treated with 1st-line chemotherapy for advanced gastric cancer
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DOI: 10.1007/s10120-017-0729-2
Abstract: BackgroundAlthough early tumor shrinkage (ETS) predictions of the efficacy and depth of response (DpR) reflects clinical outcomes in chemotherapy with epidermal growth factor receptor inhibitor regimens to treat metastatic colorectal cancer, their value in assessing… read more here.
Keywords: cancer; line chemotherapy; gastric cancer; clinical outcomes ... See more keywords
Second-line chemotherapy using taxane in patients with advanced gastric cancer who presented with severe peritoneal metastasis: a multicenter retrospective study
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DOI: 10.1007/s10147-020-01802-x
Abstract: Individuals with advanced gastric cancer (AGC) who present with severe peritoneal metastasis (SPM) have poor prognosis. This study aimed to evaluate efficacy and safety of second-line treatment for patients with such condition. This retrospective study… read more here.
Keywords: line; taxane; study; line chemotherapy ... See more keywords
Meta-analysis of FOLFIRINOX regimen as the first-line chemotherapy for locally advanced pancreatic cancer and borderline resectable pancreatic cancer
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DOI: 10.1007/s10238-018-0540-3
Abstract: The study aimed to evaluate the effectiveness of the first-line chemotherapy FOLFIRINOX in treating pancreatic cancer. Pertinent studies were derived from the PubMed, Cochrane Library and EMBASE. The outcomes were analyzed according to resection rate… read more here.
Keywords: first line; pancreatic cancer; cancer; line chemotherapy ... See more keywords
A new prognostic score comprising lactate dehydrogenase, albumin and neutrophil to lymphocyte ratio to predict sensitivity to first-line chemotherapy in patients with peripheral T-cell lymphomas
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DOI: 10.1007/s12185-017-2362-6
Abstract: No standard therapy for peripheral T-cell lymphomas (PTCLs) has been established, and treatment outcomes are poor. Upfront stem cell transplantation has been investigated in several studies, some of which have reported promising outcomes. However, some… read more here.
Keywords: chemotherapy; score; first line; line chemotherapy ... See more keywords