Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole
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DOI: 10.1038/s41598-017-14986-6
Abstract: Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 5–8 million people in Latin America. Although the nitroheterocyclic compound benznidazole has been the front-line drug for several decades, treatment failures are common.… read more here.
Keywords: genome wide; drug; front line; resistance ... See more keywords
Challenges to replace ACT as first-line drug
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DOI: 10.1186/s12936-017-1942-5
Abstract: The spread of artemisinin and partner drug resistance through Asia requires changes in first-line therapy. The traditional modus has been the replacement of one first-line anti-malarial regimen with another. The number of anti-malarial drug candidates… read more here.
Keywords: first line; act; anti malarial; drug ... See more keywords
Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru
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DOI: 10.1186/s13104-021-05832-0
Abstract: Objective To determine at two distinct time points the prevalence of resistance to ofloxacin (OFX), the representative class drug of fluoroquinolones (FQs), in M. tuberculosis isolates susceptible to first-line drugs. Results There were 279 M.… read more here.
Keywords: drug; first line; line drug; tuberculosis isolates ... See more keywords