LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis
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DOI: 10.1038/s41598-017-05143-0
Abstract: LINE-1 hypomethylation is widely accepted as marker for global genomic DNA hypomethylation, which is a frequent event in cancer. The aim of the study was to evaluate LINE-1 methylation status at different stages of gastric… read more here.
Keywords: line hypomethylation; line; hypomethylation; line methylation ... See more keywords
Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09301-2
Abstract: The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of… read more here.
Keywords: methylation; dna; multiple sclerosis; sclerosis patients ... See more keywords
Head and neck squamous cell carcinoma drives long interspersed element-1 hypomethylation in the peripheral blood mononuclear cells.
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DOI: 10.1111/odi.12944
Abstract: OBJECTIVE Alteration of long interspersed element-1 (LINE-1) methylation in peripheral blood mononuclear cells (PBMCs) has been simultaneously activated to breast carcinogenesis due to its secretion. To evaluate the effect in head and neck squamous cell… read more here.
Keywords: long interspersed; line; line methylation; cell ... See more keywords
Abstract 5475: Improved prediction of immunotherapy responses by constitutive neoantigen load and LINE-1 methylation
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DOI: 10.1158/1538-7445.am2023-5475
Abstract: Previous biomarkers such as PD-L1 expression, tumor mutation burden (TMB), and neoantigen load have limited accuracy in predicting responses to immune checkpoint inhibitor (ICI) therapy. In this work, we propose an improved predictor of ICI… read more here.
Keywords: neoantigen load; load; constitutive neoantigen; line methylation ... See more keywords
Mediterranean Diet and Particulate Matter Exposure Are Associated With LINE-1 Methylation: Results From a Cross-Sectional Study in Women
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DOI: 10.3389/fgene.2018.00514
Abstract: Emerging evidence suggests that air pollution increases the risk of cardiovascular disease (CVD) and metabolic disorders, adding to the global burden of disease attributable to lifestyle and behavioral factors. Although long interspersed nucleotide elements 1… read more here.
Keywords: methylation; pm10; exposure; line methylation ... See more keywords