SARS‐CoV‐2‐encoded inhibitors of human LINE‐1 retrotransposition
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DOI: 10.1002/jmv.28135
Abstract: The ongoing pandemic of severe acute respiratory coronavirus 2 (SARS‐CoV‐2) is causing a devastating impact on public health worldwide. However, details concerning the profound impact of SARS‐CoV‐2 on host cells remain elusive. Here, we investigated… read more here.
Keywords: inhibitors human; human line; cov encoded; line retrotransposition ... See more keywords
Nef Suppresses LINE-1 Retrotransposition through Two Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01148-22
Abstract: Human immunodeficiency viruses are pathogens of AIDS that were first discovered almost 40 years ago and continue to threaten human lives to date. While currently used anti-HIV drugs are sufficient to suppress viral loads in HIV-infected… read more here.
Keywords: hiv; anti hiv; hiv drugs; line ... See more keywords
LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor Suppressor Gene FGGY.
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DOI: 10.1158/0008-5472.can-19-0076
Abstract: Somatic Long Interspersed element-1 (LINE-1) retrotransposition (RT) is a genomic process that relates to gene disruption and tumor occurrence. However, the expression and function of LINE-1 RT in lung squamous cell carcinoma (LUSC) remains unclear.… read more here.
Keywords: lung squamous; development; line retrotransposition; cell ... See more keywords
Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals
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DOI: 10.1371/journal.pgen.1008043
Abstract: Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of… read more here.
Keywords: brain tissues; line retrotransposition; non brain; rett patients ... See more keywords