Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.6990
Abstract: This cohort study assesses the effectiveness of midazolam treatment in terminating pediatric seizures in the prehospital setting. read more here.
Keywords: midazolam prehospital; line therapy; midazolam; first line ... See more keywords
Efficacy of ramucirumab combination chemotherapy as second‐line treatment in patients with advanced adenocarcinoma of the stomach or gastroesophageal junction after exposure to checkpoint inhibitors and chemotherapy as first‐line therapy
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cancer"
DOI: 10.1002/ijc.34894
Abstract: FOLFOX plus nivolumab represents a standard of care for first‐line therapy of advanced gastroesophageal cancer (aGEC) with positive PD‐L1 expression. The efficacy of second‐line VEGFR‐2 inhibition with ramucirumab (RAM) plus chemotherapy after progression to immunochemotherapy… read more here.
Keywords: ram; line therapy; first line; second line ... See more keywords
Third‐line therapy for overactive bladder in the elderly: Nuances and considerations
Sign Up to like & getrecommendations! Published in 2022 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24965
Abstract: Overactive bladder (OAB) disproportionally affects older adults in both incidence and severity. OAB pharmacotherapy is often problematic in the elderly due to polypharmacy, adverse side effect profiles and contraindications in the setting of multiple comorbidities,… read more here.
Keywords: third line; line therapy; overactive bladder;
An analysis of factors that influence patient preference of third‐line therapy for overactive bladder
Sign Up to like & getrecommendations! Published in 2022 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.25046
Abstract: Patients with overactive bladder (OAB) refractory to first‐ and second‐line therapy may pursue third‐line therapies, including intradetrusor onabotulinum toxin‐A (BTX), peripheral tibial nerve stimulation (PTNS), and sacral neuromodulation (SNM). The factors that influence patient preference… read more here.
Keywords: line therapy; third line; factors influence; overactive bladder ... See more keywords
A randomized phase II trial of erlotinib vs. S-1 as a third- or fourth-line therapy for patients with wild-type EGFR non-small cell lung cancer (HOT1002)
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3432-4
Abstract: PurposeA high proportion of patients with wild-type EGFR non-small cell lung cancer (NSCLC) receive third-line therapy and beyond, with no prospective randomized trials addressing the issue. This study aimed to select the most suitable regimen… read more here.
Keywords: type egfr; wild type; line therapy;
Sequential therapy of refractory metastatic pancreatic cancer with 5-FU/LV/irinotecan (FOLFIRI) vs. 5-FU/LV/oxaliplatin (OFF). The PANTHEON trial (AIO PAK 0116)
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-024-05827-x
Abstract: In patients with metastatic pancreatic cancer, after failure of gemcitabine/nab-paclitaxel, this trial compares the efficacy of second-line therapy with FOLFIRI vs. OFF (1:1 randomisation) with cross-over to the vice-versa regimen as third-line therapy. The primary… read more here.
Keywords: therapy; line therapy; trial; folfiri ... See more keywords
Ramucirumab as a second line therapy for advanced HCC: a significant achievement or a wasted opportunity for personalised therapy?
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00760-0
Abstract: SummaryThe second line treatment of hepatocellular carcinoma (HCC) has recently become an exciting area of interest since new emerging options have demonstrated survival benefits versus placebo. Unfortunately, predictive biomarkers are unavailable for these treatments. Ramucirumab,… read more here.
Keywords: advanced hcc; therapy advanced; therapy; line therapy ... See more keywords
Efficacy of Docetaxel and Oxaliplatin Regimen as a Second-Line Therapy for Patients with Advanced Pancreatic Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-018-0116-1
Abstract: Background and Aim of WorkPancreatic cancer is the deadliest of the 21 most common cancers, largely because it is often identified at a late stage, we aimed to determine the control rates, and PFS for… read more here.
Keywords: line; oxaliplatin regimen; docetaxel oxaliplatin; therapy patients ... See more keywords
Real-World Data Analysis of Second-Line Antiangiogenic Targeted Treatments Following Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies and First-Line FOLFOX for Patients with Metastatic Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advances in Therapy"
DOI: 10.1007/s12325-022-02122-4
Abstract: Evidence is lacking on second-line and later treatments for patients with RAS wild-type colorectal cancer (CRC) who receive first-line anti-epidermal growth factor receptor (EGFR) antibody therapy. In this study, we explored the real-world treatment sequences,… read more here.
Keywords: treatment; second line; line therapy; line ... See more keywords
15: Identifying barriers to third‐line therapy: a patient‐centered approach to refractory overactive bladder
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2019.01.044
Abstract: 15 Identifying barriers to third-line therapy: a patient-centered approach to refractory overactive bladder A. Davenport, S. Stark, A. Quian, D. Sheyn, J. Mangel Case Western Reserve University, Cleveland, OH, Obstetrics & Gynecology, MetroHealth Medical Center,… read more here.
Keywords: medicine; third line; therapy; refractory ... See more keywords
Increasing Options for First-Line Therapy in Primary FSGS?
Sign Up to like & getrecommendations! Published in 2019 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.10.016
Abstract: F ocal segmental glomerulosclerosis (FSGS) is a common pathologic diagnosis on kidney biopsy. It denotes focal and segmental intracapillary hyaline deposition and/or focal adhesions of capillaries to Bowman’s capsule. When it occurs without underlying alternate… read more here.
Keywords: options first; therapy; first line; increasing options ... See more keywords