Prognostic Impact of Somatic Copy Number Alterations in Childhood B-Lineage Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Current Oncology Reports"
DOI: 10.1007/s11912-020-00998-5
Abstract: The high prevalence of relapse in pediatric B-lineage acute lymphoblastic leukemia (B-ALL) despite the improvements achieved using current risk stratification schemes, demands more accurate methods for outcome prediction. Here, we provide a concise overview about… read more here.
Keywords: copy number; lymphoblastic leukemia; copy; lineage acute ... See more keywords
CD2 and CD7 are Sensitive Flow Cytometry Screening Markers for T-lineage Acute Leukemia(s): a study of 465 Acute Leukemia Cases.
Sign Up to like & getrecommendations! Published in 2021 at "Human pathology"
DOI: 10.1016/j.humpath.2021.05.007
Abstract: T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) is a rare acute leukemia that expresses cytoplasmic CD3 (cCD3) and frequently lacks surface CD3. Given that routine flow cytometric testing for cCD3 may not be feasible and cCD3 interpretation may be… read more here.
Keywords: acute; lineage acute; acute leukemia; cd2 cd7 ... See more keywords
THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA
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DOI: 10.1038/ng.3909
Abstract: Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts… read more here.
Keywords: lineage acute; genomic landscape; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
Safety and efficacy of nelarabine in children and young adults with relapsed or refractory T‐lineage acute lymphoblastic leukaemia or T‐lineage lymphoblastic lymphoma: results of a phase 4 study
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14874
Abstract: Nelarabine is an antineoplastic agent approved for the treatment of relapsed/refractory T‐lineage acute lymphoblastic leukaemia (T‐ALL) or T‐lineage acute lymphoblastic lymphoma (T‐LBL). The purpose of this phase 4, multicentre, single‐arm, observational, open‐label trial was to… read more here.
Keywords: relapsed refractory; lineage; safety; lineage acute ... See more keywords
Identification of sphingosine kinase 1 as a therapeutic target in B‐lineage acute lymphoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15097
Abstract: Craig T. Wallington‐Beddoe, Vicki Xie, Daochen Tong, Jason A. Powell, Alexander C. Lewis, Lorena Davies, Stuart M. Pitson, Kenneth F. Bradstock Linda J. Bendall read more here.
Keywords: sphingosine kinase; target lineage; lineage acute; kinase therapeutic ... See more keywords
Granular B‐lineage acute lymphoblastic leukaemia mimicking acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15667
Abstract: A 65-year-old female presented with 2 months of progressive weakness and dizziness. Physical examination was unremarkable except for pallor. A full blood count showed haemoglobin concentration 59 g/l, leucocyte count 2 69 9 10/l and… read more here.
Keywords: blast cells; lymphoblastic leukaemia; lineage acute; granular lineage ... See more keywords
Blinatumomab Maintenance After Allogeneic Hematopoietic Cell Transplantation for B-lineage Acute Lymphoblastic Leukemia.
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DOI: 10.1182/blood.2021013290
Abstract: Patients with B-lineage acute lymphoblastic leukemia (ALL) are at high-risk for relapse after allogeneic hematopoietic cell transplantation (HCT). We conducted a single center phase II study evaluating the feasibility of 4 cycles of blinatumomab administered… read more here.
Keywords: allogeneic hematopoietic; lineage acute; acute lymphoblastic; cell ... See more keywords
Myelodysplastic syndrome transformed into B-lineage acute lymphoblastic leukemia: A case report
Sign Up to like & getrecommendations! Published in 2021 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v9.i19.5191
Abstract: BACKGROUND Myelodysplastic syndromes (MDSs) are a group of hematological diseases caused by expansion of an abnormal clone of hematopoietic stem cells. Primary MDS is a potentially premalignant clonal disorder that may progress to overt acute… read more here.
Keywords: lymphoblastic leukemia; case; lineage acute; acute lymphoblastic ... See more keywords