Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
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DOI: 10.1093/nar/gkad231
Abstract: Gastrulation begins when the epiblast forms the primitive streak or becomes definitive ectoderm. During this lineage bifurcation, the DNA dioxygenase TET1 has bipartite functions in transcriptional activation and repression, but the mechanisms remain unclear. By… read more here.
Keywords: tet1; dual functions; genomic context; lineage bifurcation ... See more keywords