Technical approaches and challenges to study AMPA receptors in oligodendrocyte lineage cells: Past, present, and future
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24305
Abstract: Receptors for α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPARs) are ligand‐gated ionotropic receptors for glutamate that is a major excitatory neurotransmitter in the central nervous system. AMPARs are located at postsynaptic sites of neuronal synapses where they mediate fast… read more here.
Keywords: oligodendrocyte lineage; technical approaches; lineage cells; lineage ... See more keywords
Aldh1L1 Lineage Cells Contribute to the Functional Heterogeneity Within the Cells in Glial Scars After Spinal Cord Injury Through YAP Signaling.
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DOI: 10.1002/glia.70092
Abstract: Injury to the central nervous system (CNS) such as spinal cord results in multifaceted cellular responses, including the glial scars, a structural formation of reactive glia around an area of severe tissue damage. However, the… read more here.
Keywords: aldh1l1 lineage; functional heterogeneity; lineage cells; cells glial ... See more keywords
Intracellular density is a novel indicator of differentiation stages of murine osteoblast lineage cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30135
Abstract: Osteoblasts are primary bone-making cells originating from mesenchymal stem cells (MSCs) in the bone marrow. The differentiation of MSCs to mature osteoblasts involves an intermediate stage called preosteoblasts, but the details of this process remain… read more here.
Keywords: density; osteoblast lineage; lineage cells; differentiation ... See more keywords
Conditional Mutagenesis in Oligodendrocyte Lineage Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9072-6_15
Abstract: Cell-type-specific gene targeting with the Cre/loxP system has become an indispensable technique in experimental neuroscience, particularly for the study of late-born glial cells that make myelin. A plethora of conditional mutants and Cre-expressing mouse lines… read more here.
Keywords: mutagenesis; conditional mutagenesis; mutagenesis oligodendrocyte; oligodendrocyte lineage ... See more keywords
Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108684
Abstract: Summary The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals… read more here.
Keywords: lineage; cells part; alternative lineage; lineage cells ... See more keywords
Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.09.016
Abstract: Adult oligodendrocyte progenitor cells are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential during health and disease. Recently, developments in new experimental approaches have brought about several novel insights… read more here.
Keywords: homeostasis; cells brain; brain plasticity; oligodendroglia lineage ... See more keywords
Immune cell modulation of oligodendrocyte lineage cells
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134601
Abstract: Chronic demyelination and the concomitant loss of trophic support and increased energy demands in axons are thought to contribute to neurodegeneration in a number of neurological diseases such as multiple sclerosis (MS). Adult oligodendrocyte precursor… read more here.
Keywords: modulation oligodendrocyte; immune cell; cell modulation; oligodendrocyte lineage ... See more keywords
Renal lineage cells as a source for renal regeneration
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DOI: 10.1038/pr.2017.255
Abstract: The mammalian kidney is a highly complex organ, composed of various cell types within a unique structural framework. Nonetheless, in recent years, giant leaps in our understanding of nephrogenesis and the origin of new cells… read more here.
Keywords: renal lineage; lineage cells; source renal; cells source ... See more keywords
Oligodendrocyte lineage cells and depression
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00930-0
Abstract: Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There… read more here.
Keywords: depression; lineage cells; oligodendrocyte lineage; cells depression ... See more keywords
Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01512-y
Abstract: Major depressive disorder (MDD) is a chronic debilitating illness affecting yearly 300 million people worldwide. Oligodendrocyte-lineage cells have emerged as important neuromodulators in synaptic plasticity and crucial components of MDD pathophysiology. Using the repeated social… read more here.
Keywords: stress; lineage cells; oligodendroglial lineage; lineage ... See more keywords
Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "Translational psychiatry"
DOI: 10.1038/s41398-025-03765-x
Abstract: Depression, as a serious global public health issue, is exhibiting an increasing incidence among younger populations, particularly adolescents, who face unique diagnostic challenges and poorer prognoses. Despite extensive studies on monoaminergic dysfunction, neuroinflammation, and synaptic… read more here.
Keywords: depression; lineage cells; early life; pathology ... See more keywords