Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.02.036
Abstract: Blood cell formation is classically thought to occur through a hierarchical differentiation process, although recent studies have shown that lineage commitment may occur earlier in hematopoietic stem and progenitor cells (HSPCs). The relevance to human blood… read more here.
Keywords: lineage commitment; commitment; ribosome levels; translation ... See more keywords
Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.07.002
Abstract: Blood production is essential to maintain human health, and even small perturbations in hematopoiesis can cause disease. Hematopoiesis has therefore been the focus of much research for many years. Experiments determining the lineage potentials of… read more here.
Keywords: single cell; lineage; lineage commitment; lineage tracing ... See more keywords
Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2017.02.002
Abstract: A potent regulator of bone anabolism is physical loading. However, it is currently unclear whether physical stimuli such as fluid shear within the marrow cavity is sufficient to directly drive the osteogenic lineage commitment of… read more here.
Keywords: lineage commitment; fluid flow;
Human haematopoietic stem cell lineage commitment is a continuous process
Sign Up to like & getrecommendations! Published in 2017 at "Nature cell biology"
DOI: 10.1038/ncb3493
Abstract: Blood formation is believed to occur through stepwise progression of haematopoietic stem cells (HSCs) following a tree-like hierarchy of oligo-, bi- and unipotent progenitors. However, this model is based on the analysis of predefined flow-sorted… read more here.
Keywords: lineage commitment; cell; haematopoietic stem; human haematopoietic ... See more keywords
mTORC1 activity is essential for erythropoiesis and B cell lineage commitment
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53141-1
Abstract: Mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that mediates phosphoinositide-3-kinase (PI3K)/AKT signalling. This pathway is involved in a plethora of cellular functions including protein and lipid synthesis, cell migration, cell proliferation and… read more here.
Keywords: lineage commitment; cell; role; mtorc1 ... See more keywords
Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4646
Abstract: While extracellular matrix (ECM) mechanics strongly regulate stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural… read more here.
Keywords: stem cell; egr1; lineage commitment; matrix specific ... See more keywords
Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug targets"
DOI: 10.2174/1389450118666171122141821
Abstract: Major breakthroughs in the last several decades have contributed to our knowledge of the genetic regulation in development. Although epigenetics is not a new concept, unfortunately, the role of epigenetics has not come to fruition… read more here.
Keywords: lineage commitment; stem cell; cell; hematopoietic stem ... See more keywords
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.21926
Abstract: Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-regulatory elements during lineage commitment is… read more here.
Keywords: upon lineage; lineage commitment; cis regulatory; promoter ... See more keywords
CHD-associated enhancers shape human cardiomyocyte lineage commitment
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.86206
Abstract: Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have… read more here.
Keywords: lineage commitment; human cardiomyocyte; commitment; differentiation ... See more keywords