Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion.
Sign Up to like & getrecommendations! Published in 2025 at "Nature communications"
DOI: 10.1038/s41467-025-66446-9
Abstract: The ability of adult epithelial cells to rewire their cell fate programme in response to injury has emerged as a new paradigm in stem cell biology. This plasticity supersedes the concept of strict stem cell… read more here.
Keywords: fate; plasticity; cell; cell fate ... See more keywords
Ultraefficient extracellular vesicle–guided direct reprogramming of fibroblasts into functional cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj6621
Abstract: Direct lineage conversion holds great promise in the regenerative medicine field for restoring damaged tissues using functionally engineered counterparts. However, current methods of direct lineage conversion, even those using virus-mediated transgenic expression of tumorigenic factors,… read more here.
Keywords: extracellular vesicle; direct lineage; lineage conversion; vesicle guided ... See more keywords