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Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.04.007
Abstract: Breast tumors display tremendous heterogeneity in part due to varying molecular alterations, divergent cells of origin, and differentiation. Understanding where and how this heterogeneity develops is likely important for effective breast cancers eradication. Insulin-like growth…
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Keywords:
lineage differentiation;
differentiation;
constitutive activation;
igf1r constitutive ... See more keywords
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Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac041
Abstract: BACKGROUND Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not…
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Keywords:
cell;
diffuse midline;
cell lineage;
midline gliomas ... See more keywords
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Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s358469
Abstract: Introduction Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic progenitor cells, and the AML cells are differentiation retarded which results in the hyperproliferation of those malignant tumor cells. To stop the uncontrollable…
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Keywords:
acute;
apoptosis;
mice;
differentiation ... See more keywords
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Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.987045
Abstract: Mesenchymal stem cells (MSCs) are a promising candidate for both human and veterinary regenerative medicine applications because of their abundance and ability to differentiate into several lineages. Mesenchymal stem cells are however a heterogeneous cell…
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Keywords:
tri lineage;
mscs;
method;
differentiation ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043667
Abstract: The bone cancer osteosarcoma, found mainly in adolescents, routinely forms around the growth plate/metaphysis of long bones. Bone marrow composition changes with age, shifting from a more hematopoietic to an adipocyte-rich tissue. This conversion occurs…
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Keywords:
tri lineage;
bone marrow;
bone;
differentiation ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15040386
Abstract: Tissue engineering and regenerative medicine (TERM) have paved a way for treating musculoskeletal diseases in a minimally invasive manner. The regenerative medicine cocktail involves the usage of mesenchymal stem/stromal cells (MSCs), either uncultured or culture-expanded…
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Keywords:
differentiation potential;
mesenchymal stem;
mscs;
lineage differentiation ... See more keywords