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Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01313
Abstract: Introduction of the N,N-dimethylaminoethoxy group to pyrido[3,2-d]pyrimidine led to the discovery of menin-mixed lineage leukemia (MLL) interaction inhibitor C20. C20 showed strong binding affinity to menin protein and achieved sub-micromolar potency in cell growth inhibition.…
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Keywords:
interaction;
lineage leukemia;
menin mixed;
menin ... See more keywords
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Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00989-4
Abstract: Oncogene-induced tumorigenesis results in the variation of epigenetic modifications, and in addition to promoting cell immortalization, cancer cells undergo more intense cellular stress than normal cells and depend on other support genes for survival. Chromosomal…
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Keywords:
leukemia;
acute myeloid;
mixed lineage;
matrix metallopeptidase ... See more keywords
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Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113478
Abstract: Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular processes and are extensively involved in the development of different cancers; including leukemias. As one of the accepted methods of lncRNA function is affecting…
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Keywords:
rna;
rna binding;
protein capable;
lineage leukemia ... See more keywords