Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110595
Abstract: Bioinformatic analysis of 94 patient-derived xenografts (PDXs), cell lines, and organoids (PCOs) identifies three intrinsic transcriptional subtypes of metastatic castration-resistant prostate cancer: androgen receptor (AR) pathway + prostate cancer (PC) (ARPC), mesenchymal and stem-like PC (MSPC),… read more here.
Keywords: stem like; lineage plasticity; mesenchymal stem; therapy induced ... See more keywords
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.10.033
Abstract: Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure to targeted anticancer agents. This process, termed lineage plasticity, is associated with acquired independence to an initial oncogenic driver, resulting in treatment failure. In… read more here.
Keywords: prostate; impact lineage; plasticity neuroendocrine; lineage plasticity ... See more keywords
MUC1 triggers lineage plasticity of Her2 positive mammary tumors
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02320-y
Abstract: Aberrant overexpression of mucin 1 (MUC1) and human epidermal growth factor receptor 2 (HER2) are often observed in breast cancer. However, the role of concomitant MUC1/HER2 in the development of breast cancer has not been… read more here.
Keywords: muc1; lineage plasticity; breast cancer; muc1 her2 ... See more keywords
Abstract 4753: LSD1 &8211mediated FOXA2/AP1 transcription program drives lineage plasticity in prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4753
Abstract: Background: While castration-resistant PCa (CRPC) can be further treated with second-generation androgen deprivation therapies (ADTs), the tumor can quickly generate resistance through multiple mechanisms. One critical mechanism is that tumor cells can progress to AR-indifferent… read more here.
Keywords: lineage plasticity; transcription; foxa2; crpc ... See more keywords
Abstract A058: Lineage plasticity is associated with an altered MAX cistrome through super-enhancer remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a058
Abstract: Background: Roughly 20% of late stage prostate cancer patients display a lineage conversion from typical androgen receptor (AR) driven castrate resistant prostate cancer (CRPC) to a particularly lethal neuroendocrine prostate cancer (NEPC) phenotype as a… read more here.
Keywords: lineage plasticity; cell; plasticity; max ... See more keywords
Abstract PR008: Molecular determinants of prostate cancer lineage plasticity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-pr008
Abstract: Androgen deprivation therapy (ADT) has been an effective treatment for advanced prostate cancer (PCa) for decades because PCa retains the lineage specific dependence of normal prostate tissue on androgen receptor (AR) signaling. Unfortunately, nearly all… read more here.
Keywords: lineage plasticity; prostate cancer; cancer lineage; lineage ... See more keywords
Abstract PR-02: Machine learning models to quantify lineage plasticity and neuroendocrine differentiation in high-grade prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.adi21-pr-02
Abstract: Neuroendocrine differentiation (NED) is a type of lineage plasticity that occurs in multiple cancer types either de-novo, or as a result of treatment-induced selection pressure. NED is identified by different, partially overlapping clinical, morphological and… read more here.
Keywords: lineage plasticity; prostate; cancer; prostate cancer ... See more keywords
TGFβ signaling limits lineage plasticity in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007409
Abstract: Although treatment options for localized prostate cancer (CaP) are initially effective, the five-year survival for metastatic CaP is below 30%. Mutation or deletion of the PTEN tumor suppressor is a frequent event in metastatic CaP,… read more here.
Keywords: signaling limits; limits lineage; prostate cancer; lineage plasticity ... See more keywords
Cell fate determination and lineage plasticity in prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Asian Journal of Andrology"
DOI: 10.4103/aja20231
Abstract: P cancer (PCa) initiation, progression, and therapy resistance involve genetic and epigenetic alterations that l e ad to ab err ant cel l l ine age specification and plasticity.1–3 The vast majority of primary prostate… read more here.
Keywords: lineage plasticity; cell fate; cell; prostate ... See more keywords