An arms‐race against resistance: leukemic stem cells and lineage plasticity
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13606
Abstract: Acute myeloid leukemia (AML) therapy is undergoing rapid development, but primary and acquired resistance to therapy complicates the prospect of a durable cure. Recent functional and single‐cell multi‐omics approaches have greatly expanded our knowledge of… read more here.
Keywords: lineage plasticity; stem cells; resistance; stem ... See more keywords
Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110595
Abstract: Bioinformatic analysis of 94 patient-derived xenografts (PDXs), cell lines, and organoids (PCOs) identifies three intrinsic transcriptional subtypes of metastatic castration-resistant prostate cancer: androgen receptor (AR) pathway + prostate cancer (PC) (ARPC), mesenchymal and stem-like PC (MSPC),… read more here.
Keywords: stem like; lineage plasticity; mesenchymal stem; therapy induced ... See more keywords
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.10.033
Abstract: Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure to targeted anticancer agents. This process, termed lineage plasticity, is associated with acquired independence to an initial oncogenic driver, resulting in treatment failure. In… read more here.
Keywords: prostate; impact lineage; plasticity neuroendocrine; lineage plasticity ... See more keywords
MUC1 triggers lineage plasticity of Her2 positive mammary tumors
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02320-y
Abstract: Aberrant overexpression of mucin 1 (MUC1) and human epidermal growth factor receptor 2 (HER2) are often observed in breast cancer. However, the role of concomitant MUC1/HER2 in the development of breast cancer has not been… read more here.
Keywords: muc1; lineage plasticity; breast cancer; muc1 her2 ... See more keywords
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cell Research"
DOI: 10.1038/s41422-024-01025-z
Abstract: Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression, thereby shaping tumor heterogeneity and therapy response. In castration-resistant prostate cancer (CRPC), the intricacies… read more here.
Keywords: lineage plasticity; cancer; prostate cancer; prostate ... See more keywords
Lineage plasticity and histological transformation: tumor histology as a spectrum
Sign Up to like & getrecommendations! Published in 2025 at "Cell Research"
DOI: 10.1038/s41422-025-01180-x
Abstract: Lineage plasticity, the ability of cells to transition to an alternative phenotype as a means for adaptation, is an increasingly recognized mechanism of tumor evolution and a driver of resistance to anticancer therapies. The most… read more here.
Keywords: lineage plasticity; histological transformation; histology; transformation ... See more keywords
Abstract 4753: LSD1 &8211mediated FOXA2/AP1 transcription program drives lineage plasticity in prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4753
Abstract: Background: While castration-resistant PCa (CRPC) can be further treated with second-generation androgen deprivation therapies (ADTs), the tumor can quickly generate resistance through multiple mechanisms. One critical mechanism is that tumor cells can progress to AR-indifferent… read more here.
Keywords: lineage plasticity; transcription; foxa2; crpc ... See more keywords
Abstract 5878: ZNF397 loss triggers TET2-driven epigenetic rewiring, lineage plasticity, and AR-targeted therapy resistance
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5878
Abstract: Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming, which allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms by which cancer cells exploit the epigenetic regulatory machinery to acquire lineage… read more here.
Keywords: cancer; lineage plasticity; lineage; plasticity ... See more keywords
Abstract LB217: Novel organoid models of lineage plasticity in castration resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb217
Abstract: The development of next-generation AR-targeted drugs, such as abiraterone and enzalutamide, has improved survival of patients with castration-resistant prostate cancer (CRPC). However, many patients eventually progress to therapy-resistant lethal prostate cancer. CRPC exhibits variant cellular… read more here.
Keywords: cancer; lineage plasticity; dnpc; prostate cancer ... See more keywords
Abstract 6713: RB1 and TP53 restrict lineage plasticity in prostate cancer by regulating chromatin accessibility
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6713
Abstract: Lineage plasticity has been widely recognized in various cancers as a driver of therapeutic resistance, but the molecular basis of this plasticity remains incompletely defined. Evidence from the literature reveals that the inactivation of RB1… read more here.
Keywords: rb1 tp53; lineage plasticity; chromatin accessibility; lineage ... See more keywords
Abstract A058: Lineage plasticity is associated with an altered MAX cistrome through super-enhancer remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a058
Abstract: Background: Roughly 20% of late stage prostate cancer patients display a lineage conversion from typical androgen receptor (AR) driven castrate resistant prostate cancer (CRPC) to a particularly lethal neuroendocrine prostate cancer (NEPC) phenotype as a… read more here.
Keywords: lineage plasticity; cell; plasticity; max ... See more keywords