Molecular evolution and lineage-specific expansion of the PP2C family in Zea mays
Sign Up to like & getrecommendations! Published in 2019 at "Planta"
DOI: 10.1007/s00425-019-03243-x
Abstract: 97 ZmPP2Cs were clustered into 10 subfamilies with biased subfamily evolution and lineage-specific expansion. Segmental duplication after the divergence of maize and sorghum might have led to primary expansion of ZmPP2Cs. The protein phosphatase 2C… read more here.
Keywords: evolution; expansion; pp2c family; evolution lineage ... See more keywords
Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.08.057
Abstract: Lineage-specific regulation of tumor progression by the same transcription factor is understudied. We find that levels of the FOXQ1 transcription factor, an oncogene in carcinomas, are decreased during melanoma progression. Moreover, in contrast to carcinomas,… read more here.
Keywords: melanoma; transcription; melanoma suppressor; foxq1 ... See more keywords
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.02.006
Abstract: Hematopoiesis provides an accessible system for studying the principles underlying cell-fate decisions in stem cells. Proposed models of hematopoiesis suggest that quantitative changes in lineage-specific transcription factors (LS-TFs) underlie cell-fate decisions. However, evidence for such… read more here.
Keywords: quantitative changes; cell; specific transcription; cell fate ... See more keywords
Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.08.010
Abstract: Summary Cellular membrane fluidity is a critical modulator of cell adhesion and migration, prompting us to define the systematic landscape of lineage-specific cellular fluidity throughout differentiation. Here, we have unveiled membrane fluidity landscapes in various… read more here.
Keywords: fluidity; membrane fluidity; adhesion; lineage specific ... See more keywords
Correlated evolutionary rates across genomic compartments in Annonaceae.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular phylogenetics and evolution"
DOI: 10.1016/j.ympev.2017.05.026
Abstract: The molecular clock hypothesis is an important concept in biology. Deviations from a constant rate of nucleotide substitution have been found widely among lineages, genomes, genes and individual sites. Phylogenetic research can accommodate for these… read more here.
Keywords: rate heterogeneity; specific rate; rates across; rate ... See more keywords
Lineage-specific functions of TET1 in the postimplantation mouse embryo
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3868
Abstract: The mammalian TET enzymes catalyze DNA demethylation. While they have been intensely studied as major epigenetic regulators, little is known about their physiological roles and the extent of functional redundancy following embryo implantation. Here we… read more here.
Keywords: specific functions; mouse embryo; functions tet1; lineage specific ... See more keywords
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22262-5
Abstract: Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions simultaneously depleted for genetic variation (constrained… read more here.
Keywords: human lineage; lineage; disease; brain ... See more keywords
Construction of Discrete Model of Human Pluripotency in Predicting Lineage-Specific Outcomes and Targeted Knockdowns of Essential Genes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29480-w
Abstract: A network consisting of 45 core genes was developed for the genes/proteins responsible for loss/gain of function in human pluripotent stem cells. The nodes were included on the basis of literature curation. The initial network… read more here.
Keywords: topology; model; lineage specific; human pluripotency ... See more keywords
Lineage-specific selection and the evolution of virulence in the Candida clade
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2016818118
Abstract: Significance Of the many microbial species on earth, only a small number are able to thrive in humans and cause disease. Comparison of closely related pathogenic and nonpathogenic species can therefore be useful in identifying… read more here.
Keywords: evolution virulence; virulence; selection; expression ... See more keywords
Lineage-specific insertions in T-box riboswitches modulate antibiotic binding and action
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac359
Abstract: Abstract T-box riboswitches (T-boxes) are essential RNA regulatory elements with a remarkable structural diversity, especially among bacterial pathogens. In staphylococci, all glyS T-boxes synchronize glycine supply during synthesis of nascent polypeptides and cell wall formation… read more here.
Keywords: binding; lineage specific; modulate antibiotic; box ... See more keywords
Wnt5a promotes AT1 and represses AT2 lineage specific gene expression in a cell-context-dependent manner.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac031
Abstract: Lung maturation is not limited to proper structural development, but also includes differentiation and functionality of various highly specialized alveolar cell types. Alveolar type 1 cells (AT1s) occupy nearly 95% of the alveolar surface and… read more here.
Keywords: cell; gene expression; lineage specific; wnt5a ... See more keywords