Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaab015
Abstract: Early embryos are vulnerable to environmental insults, such as medications taken by the mother. Due to increasing prevalence of hypercholesterolemia, more women of childbearing potential are taking cholesterol-lowering medications called statins. Previously, we showed that… read more here.
Keywords: mevalonate pathway; stress; specification; lineage specification ... See more keywords
Deciphering the multifaceted roles of TET proteins in T‐cell lineage specification and malignant transformation
Sign Up to like & getrecommendations! Published in 2021 at "Immunological Reviews"
DOI: 10.1111/imr.12940
Abstract: TET proteins are DNA demethylases that can oxidize 5‐methylcytosine (5mC) to generate 5‐hydroxymethylcytosine (5hmC) and other oxidized mC bases (oxi‐mCs). Importantly, TET proteins govern cell fate decisions during development of various cell types by activating… read more here.
Keywords: cell lineage; tet proteins; proteins cell; lineage specification ... See more keywords
Inflammatory Cytokine TNF-a Controls Mesenchymal Stem Fate by Regulating JMJD3 Expression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab048.479
Abstract: Abstract Introduction: Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can differentiate in to osteoblast, adipocytes and chondrocytes. Lineage specification of MSC is governed by various systemic hormones, systemic and local growth factors and… read more here.
Keywords: lineage specification; differentiation; inflammatory cytokine; mesenchymal stem ... See more keywords
Brd4‐Brd2 isoform switching coordinates pluripotent exit and Smad2‐dependent lineage specification
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DOI: 10.15252/embr.201643534
Abstract: Pluripotent stem cells (PSCs) hold great clinical potential, as they possess the capacity to differentiate into fully specialised tissues such as pancreas, liver, neurons and cardiac muscle. However, the molecular mechanisms that coordinate pluripotent exit… read more here.
Keywords: pluripotent exit; brd4 brd2; exit; lineage specification ... See more keywords
The regulatory role of pioneer factors during cardiovascular lineage specification – A mini review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.972591
Abstract: Cardiovascular disease (CVD) remains the number one cause of death worldwide. Ischemic heart disease contributes to heart failure and has considerable morbidity and mortality. Therefore, alternative therapeutic strategies are urgently needed. One class of epigenetic… read more here.
Keywords: pioneer factors; cardiovascular lineage; lineage specification; pioneer ... See more keywords
TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.940995
Abstract: TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously demonstrated a dynamic enrichment of 5hmC during T and invariant natural killer T cell lineage specification. Here,… read more here.
Keywords: tet proteins; cell; lineage specification;