Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16821-5
Abstract: Recent studies combine two novel technologies, single-cell RNA-sequencing and CRISPR-Cas9 barcode editing for elucidating developmental lineages at the whole organism level. While these studies provided several insights, they face several computational challenges. First, lineages are… read more here.
Keywords: single cell; crispr cas9; lineage tree; lineage ... See more keywords
Accurate and efficient cell lineage tree inference from noisy single cell data: the maximum likelihood perfect phylogeny approach
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz676
Abstract: MOTIVATION Cells in an organism share a common evolutionary history, called cell lineage tree. Cell lineage tree can be inferred from single cell genotypes at genomic variation sites. Cell lineage tree inference from noisy single… read more here.
Keywords: single cell; tree inference; cell lineage; cell ... See more keywords
Parameter inference for stochastic single-cell dynamics from lineage tree data
Sign Up to like & getrecommendations! Published in 2017 at "BMC Systems Biology"
DOI: 10.1186/s12918-017-0425-1
Abstract: BackgroundWith the advance of experimental techniques such as time-lapse fluorescence microscopy, the availability of single-cell trajectory data has vastly increased, and so has the demand for computational methods suitable for parameter inference with this type… read more here.
Keywords: single cell; parameter inference; cell; lineage tree ... See more keywords