A Newly Identified Spike Protein Targeted Linear B-Cell Epitope Based Dissolvable Microneedle Array Successfully Eliciting Neutralizing Activities against SARS-CoV-2 Wild-Type Strain in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207474
Abstract: Vaccination is a cost-effective medical intervention. Inactivated whole virusor large protein fragments-based severe acute respiratory syndrome coronavirus (SARS-CoV-2) vaccines have high unnecessary antigenic load to induce allergenicity and/orreactogenicity, which can be avoided by peptide vaccines… read more here.
Keywords: cell epitope; linear cell; cov wild; sars cov ... See more keywords
Identification of three linear B cell epitopes against non-structural protein 3ABC of FMDV using monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10081-0
Abstract: Foot-and-mouth disease virus (FMDV) has led to serious losses in the farming industry worldwide, particularly in cattle and swine. In developing countries, the control and eradication of FMD rely upon vaccination, in which the inactivated… read more here.
Keywords: cell epitopes; linear cell; monoclonal antibodies; three linear ... See more keywords
Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102911
Abstract: Abstract Background Given the unceasing worldwide surge in COVID-19 cases, there is an imperative need to develop highly specific and sensitive serology assays to define exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Methods… read more here.
Keywords: sars cov; disease severity; cell epitopes; linear cell ... See more keywords
Biochemical analysis and identification of linear B‐cell epitopes from recombinant Sm21.7 antigen from Schistosoma mansoni
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.05.019
Abstract: HighlightsStructural and physico‐chemical properties of Sm21.7 are described.Nine peptides are identified as linear B‐cell epitopes of Sm21.7 protein.Several epitopes within the DLC‐domain are recognized by Sm21.7‐immunized mice sera.Implications for the development and use of vaccines… read more here.
Keywords: cell epitopes; linear cell; antigen; spectroscopy ... See more keywords
A comparative analysis of amino acid encoding schemes for the prediction of flexible length linear B-cell epitopes
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac356
Abstract: Linear B-cell epitopes have a prominent role in the development of peptide-based vaccines and disease diagnosis. High variability in the length of these epitopes is a major reason for low accuracy in their prediction. Most… read more here.
Keywords: cell; flexible length; prediction; cell epitopes ... See more keywords
Capacity Evaluation of MIMO Channel With One Leaky Coaxial Cable Used as Two Antennas Over Linear-Cell Environments
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Vehicular Technology"
DOI: 10.1109/tvt.2016.2612683
Abstract: Leaky coaxial (LCX) cable is widely used in wireless communication systems as an antenna, especially for a long and narrow area called the linear-cell environment. The general usage of LCX cable is that it can… read more here.
Keywords: cell environments; capacity; linear cell; cable ... See more keywords
Identification of a linear B-cell epitope on the Schistosoma japonicum saposin protein, SjSAP4: Potential as a component of a multi-epitope diagnostic assay
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010619
Abstract: Background Schistosoma japonicum is one of three major species of blood flukes causing schistosomiasis, a disease, which continues to be a major public health issue in the Philippines. SjSAP4, a member of a multigene family… read more here.
Keywords: cell; multi epitope; peptide; schistosomiasis ... See more keywords
In-silico identification of linear B-cell epitopes in specific proteins of Bartonella bacilliformis for the serological diagnosis of Carrion's disease.
Sign Up to like & getrecommendations! Published in 2023 at "PLoS neglected tropical diseases"
DOI: 10.1371/journal.pntd.0011321
Abstract: Carrion´s disease is caused by Bartonella bacilliformis, it is a Gram-negative pleomorphic bacterium. B. bacilliformis is transmitted by Lutzomyia verrucarum in endemic areas of the Peruvian Inter-Andean valleys. Additionally, the pathogenicity of B. bacilliformis involves… read more here.
Keywords: specific proteins; epitopes specific; carrion disease; cell epitopes ... See more keywords
Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea Virus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.785293
Abstract: Porcine epidemic diarrhea virus (PEDV) is the causative agent of PED, an enteric disease that causes high mortality rates in piglets. PEDV is an alphacoronavirus that has high genetic diversity. Insights into neutralizing B-cell epitopes… read more here.
Keywords: cell; cell epitopes; porcine epidemic; pedv ... See more keywords
DeepLBCEPred: A Bi-LSTM and multi-scale CNN-based deep learning method for predicting linear B-cell epitopes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1117027
Abstract: The epitope is the site where antigens and antibodies interact and is vital to understanding the immune system. Experimental identification of linear B-cell epitopes (BCEs) is expensive, is labor-consuming, and has a low throughput. Although… read more here.
Keywords: predicting linear; learning; learning method; cell epitopes ... See more keywords
In Silico Prediction of Cross-Reactive Epitopes of Tropomyosin from Shrimp and Other Arthropods Involved in Allergy
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092667
Abstract: Tropomyosin in shellfish is considered a major cross-reactive allergen in house dust mites and cockroaches; however, the specific epitopes have not been elucidated. Therefore, this study aimed to identify the consensus antigenic determinant among shrimp,… read more here.
Keywords: cell; cross reactive; cell epitope; cell epitopes ... See more keywords