SLiMAn: An Integrative Web Server for Exploring Short Linear Motif-Mediated Interactions in Interactomes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00964
Abstract: Cells express thousands of macromolecules, and their functioning relies on multiple networks of intermolecular interactions. These interactions can be experimentally determined at different spatial and temporal resolutions. But, physical interfaces are not often delineated directly,… read more here.
Keywords: web server; linear motif; short linear;
A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01160-9
Abstract: Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs), which are formed from multiple copies of ~30 different nucleoporins (Nups) and inserted into the double nuclear membrane. Many of these Nups are organized into subcomplexes, of… read more here.
Keywords: short linear; nup82 complex; pre assembled; linear motif ... See more keywords
A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114647119
Abstract: Significance Successful microbial infections typically involve the subversion of host immune pathways by pathogen-specific virulence factors. Here, we uncovered that viruses and bacteria independently evolved effectors targeting the same conserved loop of the mitogen-activated protein… read more here.
Keywords: viral bacterial; linear motif; kinase; bacterial pathogens ... See more keywords
The eukaryotic linear motif resource – 2018 update
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1077
Abstract: Abstract Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif… read more here.
Keywords: motif resource; motif; resource 2018; eukaryotic linear ... See more keywords
Thousands of protein linear motif classes may still be undiscovered
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0248841
Abstract: Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of motif classes including thousands of motif instances are known. Our theory estimates how many motif classes remain undiscovered. As commonly done, we describe… read more here.
Keywords: motif; amino acid; classes may; motif discriminating ... See more keywords