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Published in 2018 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9288-2
Abstract: Peptide-based therapeutics have attracted increasing attention due to their unique properties in comparison to small molecule drugs and recombinant biologics [1]. With moderate size and suitable surface area, peptides possess enormous potential in drug discovery…
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Keywords:
cyclophane braced;
peptide macrocycles;
braced peptide;
arylation ... See more keywords
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Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.110980
Abstract: The two branched peptides (AAHAWG)4-PWT2 and (HAWG)4-PWT2 where synthesized by mounting linear peptides on a cyclam-based scaffold (PWT2), provided with four maleimide chains, through a thio-Michael reaction. The purpose of this study was primarily to…
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Keywords:
coordination;
peptide;
hawg;
linear peptides ... See more keywords
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Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2189107
Abstract: Two new linear peptides, penicamides A and B (1 and 2), together with four known analogous were isolated from the extracts of the marine-derived fungus Penicillium sp. SCSIO 41512. Their structures were elucidated by analysis…
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Keywords:
new linear;
two new;
derived fungus;
fungus penicillium ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041634
Abstract: We present the construction and screening of yeast display libraries of post-translationally modified peptides wherein site-selective enzymatic treatment of linear peptides is achieved using bacterial transglutaminase. To this end, we developed two alternative routes, namely…
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Keywords:
peptide;
yeast display;
display libraries;
treated peptides ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25163576
Abstract: Peptides represent an important class of biologically active molecules with high potential for the development of diagnostic and therapeutic agents due to their structural diversity, favourable pharmacokinetic properties, and synthetic availability. However, the widespread use…
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Keywords:
bond surrogates;
disubstituted triazoles;
bond;
triazoles amide ... See more keywords
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Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020666
Abstract: RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging.…
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Keywords:
modified linear;
cancer;
cell lines;
linear peptides ... See more keywords
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1
Published in 2022 at "Toxins"
DOI: 10.3390/toxins14120854
Abstract: Spider venom is a complex mixture of bioactive components. Previously, we identified two linear peptides in Lycosa poonaensis venom using mass spectrometric analysis and predicted the presence of more linear peptides therein. In this study,…
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Keywords:
lycosa poonaensis;
venom;
analysis;
spider ... See more keywords