N‐terminal Cationic Modification of Linear Pyrrole‐Imidazole Polyamide Improves Its Binding to DNA
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DOI: 10.1002/cbic.202200124
Abstract: Pyrrole‐imidazole polyamides (PIPs) bind to double‐stranded DNA (dsDNA) with varied sequence selectivity. We synthesized linear PIPs that can bind to narrow minor grooves of polypurine/polypyrimidine sequences and target long recognition sequences but have lower molecular… read more here.
Keywords: pyrrole imidazole; modification linear; terminal cationic; cationic modification ... See more keywords