ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐κB activation by recognizing linear ubiquitin chains
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14323
Abstract: Linear ubiquitin chains play pivotal roles in immune signaling by augmenting NF‐κB activation and suppressing programmed cell death induced by various stimuli. A20‐binding inhibitor of NF‐κB 1 (ABIN1) binds to linear ubiquitin chains and attenuates… read more here.
Keywords: autophagy receptor; attenuates activation; ubiquitin chains; linear ubiquitin ... See more keywords
NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-018-09868-5
Abstract: Nuclear factor-κB (NF-κB) activation plays a central role in immunity and inflammation. In the canonical NF-κB activation pathway, linear polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) are specifically recognized by the Npl4… read more here.
Keywords: assignments nzf; resonance assignments; nzf domain; linear ubiquitin ... See more keywords
The linear ubiquitin E3 ligase-Relish pathway is involved in the regulation of proteostasis in Drosophila muscle during aging.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.135
Abstract: Linear ubiquitination is an atypic ubiquitination process that directly connects the N- and C-termini of ubiquitin and is catalyzed by HOIL-1-interacting protein (HOIP). It is involved in the immune response or apoptosis by activating the… read more here.
Keywords: lubel; muscle; ubiquitin ligase; linear ubiquitin ... See more keywords
Legionella dismantles linear ubiquitin
Sign Up to like & getrecommendations! Published in 2019 at "Nature Microbiology"
DOI: 10.1038/s41564-019-0515-5
Abstract: Host cells assemble linear ubiquitin chains to activate immune signalling during bacterial infection. A new study reveals that Legionella pneumophila — the causative agent of Legionnaires’ disease — produces an enzyme that specifically disassembles these… read more here.
Keywords: legionella dismantles; dismantles linear; microbiology; linear ubiquitin ... See more keywords
Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116776119
Abstract: Significance Shigella flexneri, a deleterious bacterium, causes massive human infection cases and deaths worldwide. To facilitate survival and replication in infected host cells, S. flexneri can secrete two highly similar E3 ligase effectors, IpaH1.4 and… read more here.
Keywords: chain assembly; shigella flexneri; ubiquitin chain; assembly complex ... See more keywords
Role of linear ubiquitination in inflammatory responses and tissue homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac047
Abstract: Polyubiquitination is a post-translational modification involved in a wide range of immunological events, including inflammatory responses, immune cell differentiation, and development of inflammatory diseases. The versatile functions of polyubiquitination are based on different types of… read more here.
Keywords: inflammatory responses; role linear; linear ubiquitin; linear ubiquitination ... See more keywords
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad002
Abstract: Abstract While linear ubiquitin plays critical roles in multiple cell signaling pathways, few substrates have been identified. Global profiling of linear ubiquitin substrates represents a significant challenge because of the low endogenous level of linear… read more here.
Keywords: bio orthogonal; otulin; linear ubiquitin; linear ubiquitination ... See more keywords