Linear ubiquitination‐induced necrotic tumor remodeling elicits immune evasion
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14623
Abstract: Tumor‐elicited inflammation confers tumorigenic properties, including cell death resistance, proliferation, or immune evasion. To focus on inflammatory signaling in tumors, we investigated linear ubiquitination, which enhances the nuclear factor‐κB signaling pathway and prevents extrinsic programmed… read more here.
Keywords: immune evasion; ubiquitination induced; linear ubiquitination; tumor ... See more keywords
Linear ubiquitination modification of NR6A1 by LUBAC inhibits RIPK3 kinase activity and attenuates apoptosis of vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23091
Abstract: Nuclear receptor subfamily 6 group A member 1 (NR6A1) is involved in promoting the apoptotic process of vascular smooth muscle cells (VSMCs) which is a critical process involved in atherosclerosis, but the action mechanism remains… read more here.
Keywords: lubac; apoptosis; muscle cells; vascular smooth ... See more keywords
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α
Sign Up to like & getrecommendations! Published in 2024 at "Oncogenesis"
DOI: 10.1038/s41389-024-00508-3
Abstract: Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and tumorigenesis. Linear ubiquitin chain assembly complex (LUBAC), the only known ubiquitin ligase capable of catalyzing protein linear ubiquitination to date, is implicated in cell… read more here.
Keywords: lung cancer; tumorigenesis; linear ubiquitination; lubac ... See more keywords
Linear ubiquitination regulates the KSHV replication and transcription activator protein to control infection
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49887-6
Abstract: Like many other viruses, KSHV has two life cycle modes: the latent phase and the lytic phase. The RTA protein from KSHV is essential for lytic reactivation, but how this protein’s activity is regulated is… read more here.
Keywords: rta; linear ubiquitination; protein; ubiquitination regulates ... See more keywords
Role of linear ubiquitination in inflammatory responses and tissue homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac047
Abstract: Polyubiquitination is a post-translational modification involved in a wide range of immunological events, including inflammatory responses, immune cell differentiation, and development of inflammatory diseases. The versatile functions of polyubiquitination are based on different types of… read more here.
Keywords: inflammatory responses; role linear; linear ubiquitin; linear ubiquitination ... See more keywords
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad002
Abstract: Abstract While linear ubiquitin plays critical roles in multiple cell signaling pathways, few substrates have been identified. Global profiling of linear ubiquitin substrates represents a significant challenge because of the low endogenous level of linear… read more here.
Keywords: bio orthogonal; otulin; linear ubiquitin; linear ubiquitination ... See more keywords
Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.686395
Abstract: Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU deubiquitinase with linear linkage specificity, FAM105B)… read more here.
Keywords: linear ubiquitination; human proteome; lubac otulin; interacting proteins ... See more keywords