Modulating Nrf2 transcription factor activity: Revealing the regulatory mechanisms of antioxidant defenses during hibernation in 13-lined ground squirrels.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3627
Abstract: Mammalian hibernators undergo major behavioural, physiological and biochemical changes to survive hypothermia, ischaemia-reperfusion and finite fuel reserves during days or weeks of continuous torpor. During hibernation, the 13-lined ground squirrel (Ictidomys tridecemlineatus) undergoes a global… read more here.
Keywords: transcription; nrf2 transcription; hibernation lined; antioxidant defenses ... See more keywords
Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00884
Abstract: Hibernation is an evolutionary adaptation that affords some mammals the ability to exploit the cold to achieve extreme metabolic depression (torpor) while avoiding ischemia/reperfusion or hemorrhagic shock injuries. Hibernators cycle periodically out of torpor, restoring… read more here.
Keywords: ground; numb back; comfortably numb; plasma metabolomics ... See more keywords
Platelet proteome dynamics in hibernating 13-lined ground squirrels.
Sign Up to like & getrecommendations! Published in 2021 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00078.2021
Abstract: Hibernating mammals undergo a dramatic drop in temperature and blood flow during torpor, yet avoid stasis blood clotting through mechanisms that remain unspecified. The effects of hibernation on hemostasis are especially complex, as cold temperatures… read more here.
Keywords: proteome dynamics; ground; ground squirrels; cold storage ... See more keywords
Identification of a lipid-rich depot in the orbital cavity of the thirteen-lined ground squirrel
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.195750
Abstract: ABSTRACT We discovered a previously undescribed orbital lipid depot in the thirteen-lined ground squirrel during the first ever magnetic resonance image (MRI) of this common experimental model of mammalian hibernation. In animals housed at constant… read more here.
Keywords: lined ground; ground squirrel; thirteen lined; depot ... See more keywords