A severe linezolid‐induced rhabdomyolysis and lactic acidosis in Leigh syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12328
Abstract: To the Editor, Recently, De Vries et al. reported the results of a Delphi-based workshop to develop consensus guidelines for physicians prescribing drugs for patients with mitochondrial diseases. The pharmacological management of these subjects is… read more here.
Keywords: acidosis; leigh syndrome; lactic acidosis; rhabdomyolysis ... See more keywords
Classification tree analysis based on machine learning for predicting linezolid-induced thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2021.02.014
Abstract: Linezolid-induced thrombocytopenia is related to linezolid exposure, baseline platelet count and patient background. Although the relationship usually reflects the time of onset of thrombocytopenia, if the platelet maturation process is taken into account, the platelet… read more here.
Keywords: linezolid induced; platelet count; induced thrombocytopenia; analysis based ... See more keywords
Initial trough concentration may be beneficial in preventing linezolid-induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2022.2043538
Abstract: Abstract We assessed whether prospective therapeutic drug monitoring to optimise the therapeutic range could prevent linezolid-induced thrombocytopenia. This prospective interventional study was conducted from September 2017 to October 2020 among 37 adult patients receiving linezolid.… read more here.
Keywords: linezolid induced; therapeutic range; range; induced thrombocytopenia ... See more keywords
External evaluation of population pharmacokinetics and pharmacodynamics in linezolid-induced thrombocytopenia: the transferability of published models to different hospitalized patients.
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000816
Abstract: OBJECTIVES The objective of the present study was to perform an external evaluation of published linezolid population pharmacokinetic and pharmacodynamic models, in order to evaluate the predictive performance using an independent dataset. Another aim was… read more here.
Keywords: pharmacokinetic pharmacodynamic; external evaluation; population; population pharmacokinetic ... See more keywords
A case of linezolid-induced SIADH in elderly and a review of the literature.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202208_29505
Abstract: INTRODUCTION Linezolid is a synthetic oxazolidinone antimicrobial drug with a broad spectrum and a unique mechanism of inhibiting resistant pathogenic strains, and it was approved by the Food and Drug Administration (FDA) in April 2000.… read more here.
Keywords: case linezolid; linezolid induced; induced siadh; sodium ... See more keywords