Resistance mechanisms and clinical characteristics of linezolid-resistant Enterococcus faecium isolates: A single-centre study in South Korea.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2017.09.009
Abstract: OBJECTIVES This study aimed to determine the prevalence of linezolid-resistant (LR) vancomycin-resistant enterococci and to investigate the mechanisms of linezolid resistance with clinical and microbiological characterisation. METHODS All vancomycin-resistant Enterococcus faecium (VREF) isolated from blood… read more here.
Keywords: vref; linezolid resistance; resistance; resistant enterococcus ... See more keywords
Mutations in Genes Encoding 23S rRNA and FadD32 May be Associated with Linezolid Resistance in Mycobacteroides abscessus.
Sign Up to like & getrecommendations! Published in 2023 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0068
Abstract: Linezolid is one of the antibiotics used to treat the Mycobacteroides abscessus infection. However, linezolid-resistance mechanisms of this organism are not well understood. The objective of this study was to identify possible linezolid-resistance determinants in… read more here.
Keywords: mycobacteroides abscessus; linezolid resistance; resistance; 23s rrna ... See more keywords
Linezolid resistance in Enterococcus faecium and Enterococcus faecalis from hospitalized patients in Ireland: high prevalence of the MDR genes optrA and poxtA in isolates with diverse genetic backgrounds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaa075
Abstract: Abstract Objectives To investigate the prevalence of the optrA, poxtA and cfr linezolid resistance genes in linezolid-resistant enterococci from Irish hospitals and to characterize associated plasmids. Methods One hundred and fifty-four linezolid-resistant isolates recovered in… read more here.
Keywords: optra poxta; linezolid resistance; resistance; faecium ... See more keywords
Presence of optrA-mediated linezolid resistance in multiple lineages and plasmids of Enterococcus faecalis revealed by long read sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001137
Abstract: Transferable linezolid resistance due to optrA, poxtA, cfr and cfr-like genes is increasingly detected in enterococci associated with animals and humans globally. We aimed to characterize the genetic environment of optrA in linezolid-resistant Enterococcus faecalis… read more here.
Keywords: linezolid resistance; enterococcus faecalis; resistance; long read ... See more keywords
Recommendations To Address the Difficulties Encountered When Determining Linezolid Resistance from Whole-Genome Sequencing Data
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00613-18
Abstract: ABSTRACT Mutations associated with linezolid resistance within the V domain of 23S rRNA are annotated using an Escherichia coli numbering system. The 23S rRNA gene varies in length, nucleotide sequence, and copy number among bacterial… read more here.
Keywords: linezolid resistance; genome sequencing; sequencing data; whole genome ... See more keywords
Research progress on the oxazolidinone drug linezolid resistance.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202009_23009
Abstract: OBJECTIVE The oxazolidinone drug linezolid is mainly used for severe infections caused by multidrug-resistant Gram-positive bacteria. However, emerging linezolid resistance is aggravating difficulties in the treatment of certain infectious diseases. The objective of this review… read more here.
Keywords: oxazolidinone drug; linezolid resistance; resistance; drug linezolid ... See more keywords
Quantitative Proteomics Analysis of Membrane Proteins in Enterococcus faecalis With Low-Level Linezolid-Resistance
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01698
Abstract: Despite increasing reports of low-level linezolid-resistant enterococci worldwide, the mechanism of this resistance remains poorly understood. Previous transcriptome studies of low-level linezolid-resistant Enterococcus faecalis isolates have demonstrated a number of significantly up-regulated genes potentially involved… read more here.
Keywords: linezolid resistance; resistance; quantitative proteomics; level linezolid ... See more keywords
Sentinel Surveillance Reveals Emerging Daptomycin-Resistant ST736 Enterococcus faecium and Multiple Mechanisms of Linezolid Resistance in Enterococci in the United States
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.807398
Abstract: Enterococcus faecalis and faecium with resistance to daptomycin and/or linezolid are emerging globally. We present the genomic characterization of daptomycin- and linezolid-resistant E. faecalis and E. faecium surveillance isolates from the United States, 2013–2016. Daptomycin… read more here.
Keywords: surveillance; daptomycin; linezolid resistance; resistance ... See more keywords
Evidence of Linezolid Resistance and Virulence Factors in Enterococcus spp. Isolates from Wild and Domestic Ruminants, Italy
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11020223
Abstract: The aim of this study was to evaluate the resistance patterns against selected critically and highly important antibiotics (quinupristin/dalfopristin, vancomycin, and linezolid) in 48 Enterococcus isolates obtained from wild (red deer and Apennine chamois) and… read more here.
Keywords: apennine chamois; linezolid resistance; resistance virulence; virulence ... See more keywords
Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in Germany
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DOI: 10.3390/antibiotics11121802
Abstract: Resistance of methicillin-resistant Staphylococcus aureus (MRSA) from food and livestock to last resort antibiotics such as linezolid is highly concerning, since treatment options for infections in humans might be diminished. Known mechanisms of linezolid resistance… read more here.
Keywords: resistance; mrsa; linezolid resistance; food livestock ... See more keywords
Linezolid-Resistant Enterococcus spp. Isolates from Foods of Animal Origin—The Genetic Basis of Acquired Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11070975
Abstract: Enterococci are important opportunistic pathogens with the capacity to acquire and spread antibiotic resistance. At present, linezolid-resistant enterococci (LRE) pose a great challenge. Linezolid is considered as a last resort antibiotic in the treatment of… read more here.
Keywords: foods animal; animal origin; linezolid resistance; linezolid resistant ... See more keywords