Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination
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DOI: 10.1021/acs.analchem.2c01320
Abstract: AZD7442 (tixagevimab [AZD8895]/cilgavimab [AZD1061]) is a monoclonal antibody (mAb) combination in development for the prevention and treatment of coronavirus disease 2019. Traditionally, bioanalysis of mAbs is performed using ligand binding assays (LBAs), which offer sensitivity,… read more here.
Keywords: quantification; sensitivity; azd7442; lining fluid ... See more keywords
Chorioamnionitis alters lung surfactant lipidome in newborns with respiratory distress syndrome
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DOI: 10.1038/s41390-021-01371-3
Abstract: Chorioamnionitis is associated with preterm delivery and morbidities; its role in lung disease is controversial. The aim of this study is to assess the effect of chorioamnionitis on metabolite and lipid profiles of epithelial lining… read more here.
Keywords: lining fluid; tracheal aspirates; newborns respiratory; epithelial lining ... See more keywords
Epithelial lining fluid concentrations of ceftriaxone in children with community‐acquired pneumonia
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DOI: 10.1111/bcp.15616
Abstract: Ceftriaxone is widely used in children with community‐acquired pneumonia. Currently, there are no available data regarding epithelial lining fluid (ELF) concentrations of ceftriaxone in children. Thus, blood and bronchoalveolar lavage fluids samples were collected by… read more here.
Keywords: children community; concentrations ceftriaxone; lining fluid; acquired pneumonia ... See more keywords
Pharmacokinetics and Penetration of Sitafloxacin into Alveolar Epithelial Lining Fluid in Critically Ill Thai Patients with Pneumonia
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DOI: 10.1128/aac.00800-19
Abstract: Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio… read more here.
Keywords: critically ill; lining fluid; ill thai; fluid ... See more keywords
Evaluation of Epithelial Lining Fluid Concentration of Amikacin in Critically Ill Patients With Ventilator-Associated Pneumonia
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DOI: 10.1177/0885066618754784
Abstract: Introduction: Classically, aminoglycosides are known to have low penetration into the lung tissue. So far, no study has been conducted on human adult patients to evaluate amikacin concentration in epithelial lining fluid (ELF) of the… read more here.
Keywords: lining fluid; concentration amikacin; critically ill; patients ventilator ... See more keywords