Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007615
Abstract: Synonymous mutations do not alter the specified amino acid but may alter the structure or function of an mRNA in ways that impact fitness. There are few examples in the literature, however, in which the… read more here.
Keywords: weak link; synonymous mutations; link enzyme; growth rate ... See more keywords
Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.53535
Abstract: New enzymes often evolve by gene amplification and divergence. Previous experimental studies have followed the evolutionary trajectory of an amplified gene, but have not considered mutations elsewhere in the genome when fitness is limited by… read more here.
Keywords: mutations elsewhere; link enzyme; weak link; elsewhere genome ... See more keywords