JPT2: The missing link between intracellular Ca2+ release channels and NAADP?
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102405
Abstract: NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca2+ from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors (RyR1). How NAADP activates these… read more here.
Keywords: link intracellular; link; ca2 release; jpt2 missing ... See more keywords
Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society Transactions"
DOI: 10.1042/bst20170508
Abstract: Alterations in excitation–contraction coupling and elevated intracellular sodium (Nai) are hallmarks of pathological cardiac remodelling that underline contractile dysfunction. In addition, changes in cardiac metabolism are observed in cardiac hypertrophy and heart failure (HF) that… read more here.
Keywords: cardiac hypertrophy; link intracellular; causal link; hypertrophy ... See more keywords