Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2019.09.001
Abstract: The post-translational modification of proteins by O-linked N-acetylglucosamine (O-GlcNAc) dynamically programmes cellular physiology to maintain homoeostasis and tailor biochemical pathways to meet context-dependent cellular needs. Despite diverse roles of played by O-GlcNAc, only two enzymes… read more here.
Keywords: glcnac; linked acetylglucosamine; mechanisms regulating; acetylglucosamine glcnac ... See more keywords
Preferred conformational structures of disaccharides with β-1,4-linked N-acetylglucosamine and D-mannose in the gas phase: A tree-step computational approach study
Sign Up to like & getrecommendations! Published in 2018 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2018.07.014
Abstract: Abstract N-glycans are highly crucial to the potential application prospect of glycoprotein. However, its structural diversity and instability severely limit its further research. Here we apply the tree-step computational approach to investigate preferred structures of… read more here.
Keywords: disaccharides linked; step computational; computational approach; structures disaccharides ... See more keywords
O-linked β-N-acetylglucosamine transferase is involved in pro-opiomelanocortin gene expression in mouse pituitary corticotroph AtT-20 cells
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134407
Abstract: Glucocorticoids and glucocorticoid receptors (GRs) suppress pituitary pro-opiomelanocortin (Pomc) gene expression. O-linked β-N-acetylglucosamine (O-GlcNAc) modification, mediated by O-GlcNAc transferase (OGT), plays an important role during gene transcription. However, whether OGT is involved in the GR-mediated… read more here.
Keywords: gene expression; pro opiomelanocortin; expression; corticotroph ... See more keywords
Precision Mapping of O-Linked N-Acetylglucosamine Sites in Proteins using Ultraviolet Photodissociation Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c04710
Abstract: Despite its central importance as a regulator of cellular physiology, the identification and precise mapping of O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (PTM) sites in proteins by mass spectrometry (MS) remains a considerable technical challenge. This… read more here.
Keywords: photodissociation; mapping; mass spectrometry; sites proteins ... See more keywords
FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00708
Abstract: The hexosamine biosynthetic pathway (HBP) generates the substrate for the O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins. The HBP also serves as a stress sensor and has been reported to be involved with nuclear factor of… read more here.
Keywords: glcnac; glcnac levels; fgf23 induction; induction linked ... See more keywords
O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.852115
Abstract: The O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins dynamically regulates protein function, localization, stability, and interactions. This post-translational modification is intimately linked to cardiovascular disease, including hypertension. An increasing number of studies suggest that components of… read more here.
Keywords: modification; linked acetylglucosamine; hypertension; acetylglucosamine modification ... See more keywords
Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26041037
Abstract: O-GlcNAcylation is a posttranslational modification that occurs at serine and threonine residues of protein substrates by the addition of O-linked β-d-N-acetylglucosamine (GlcNAc) moiety. Two enzymes are involved in this modification: O-GlcNac transferase (OGT), which attaches… read more here.
Keywords: transferase; assays probe; probe linked; overview assays ... See more keywords