Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies
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DOI: 10.1039/d4ra05799f
Abstract: To discover promising therapeutic agents, novel diaryl pyrimidine linked acyl thiourea derivatives (6a–j) were designed and synthesized via straightforward and multistep synthesis. The structure of these derivatives (6a–j) was confirmed by FTIR, 1H, and 13C… read more here.
Keywords: amylase proteinase; pyrimidine linked; linked acyl; pyrimidine ... See more keywords