Role of sialylation of N-linked glycans in prion pathogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cell and tissue research"
DOI: 10.1007/s00441-022-03584-2
Abstract: Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of the prion protein or PrPC. PrPC and PrPSc are posttranslationally modified with N-linked glycans, which are sialylated at… read more here.
Keywords: role sialylation; linked glycans; strain; prion ... See more keywords
Functional characterization of the Sporothrix schenckii Ktr4 and Ktr5, mannosyltransferases involved in the N-linked glycosylation pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2018.02.004
Abstract: Sporothrix schenckii is one of the causative agents of the deep-seated mycosis sporotrichosis, a fungal infection with worldwide distribution. Fungus-specific molecules and biosynthetic pathways are potential targets for the development of new antifungal drugs. The… read more here.
Keywords: sporothrix schenckii; schenckii; linked glycans; family ... See more keywords
Mass Spectrometry Imaging of N-Linked Glycans in a Formalin-Fixed Paraffin-Embedded Human Prostate by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00822
Abstract: N-Linked glycans are structurally diverse polysaccharides that represent significant biological relevance due to their involvement in disease progression and cancer. Due to their complex nature, N-linked glycans pose many analytical challenges requiring the continued development… read more here.
Keywords: assisted laser; matrix assisted; laser desorption; linked glycans ... See more keywords
Accommodation of In-Register N-Linked Glycans on Prion Protein Amyloid Cores.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00635
Abstract: Although prion protein fibrils can have either parallel-in-register intermolecular β-sheet (PIRIBS) or, probably, β-solenoid architectures, the plausibility of PIRIBS architectures for the usually glycosylated natural prion strains has been questioned based the expectation that such… read more here.
Keywords: register linked; linked glycans; register; prion protein ... See more keywords
Preparation of ordered mesoporous carbon material based on poly-dopamine and its application in selective enrichment of N-linked glycans
Sign Up to like & getrecommendations! Published in 2018 at "Analytical Methods"
DOI: 10.1039/c7ay02800h
Abstract: Protein glycosylation has been demonstrated to be associated with numerous diseases. Taking into consideration of low abundance of N-linked glycans, the pretreatment of a biological sample is a key problem. In this study, a highly… read more here.
Keywords: linked glycans; carbon material; material; mesoporous carbon ... See more keywords
Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt02932g
Abstract: Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation in the spike (S) protein.… read more here.
Keywords: spike proteins; linked glycans; concanavalin targeting; proteins influence ... See more keywords
High expression of tissue O-linked glycans is associated with a malignant phenotype of cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of International Medical Research"
DOI: 10.1177/0300060520976864
Abstract: Objective This study aimed to investigate the expression of O-linked glycoprotein glycans in tissue of patients with cholangiocarcinoma compared with adjacent normal tissue. Methods Sixty patients with cholangiocarcinoma were included in the study. Permethylated O-linked… read more here.
Keywords: linked glycans; tissue; patients cholangiocarcinoma; expression ... See more keywords
Removal of N-linked glycans in cellobiohydrolase Cel7A from Trichoderma reesei reveals higher activity and binding affinity on crystalline cellulose
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-020-01779-9
Abstract: Cellobiohydrolase from glycoside hydrolase family 7 is a major component of commercial enzymatic mixtures for lignocellulosic biomass degradation. For many years, Trichoderma reesei Cel7A (TrCel7A) has served as a model to understand structure–function relationships of… read more here.
Keywords: linked glycans; removal linked; trichoderma reesei; higher activity ... See more keywords
Silencing of OCH1 unveils the role of Sporothrix schenckii N-linked glycans during the host–fungus interaction
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s185037
Abstract: Background Sporothrix schenckii is a neglected fungal pathogen for the human being and other mammals. In several fungal systems, Och1 is a Golgi α1,6-mannosyltransferase with a key function in the synthesis of N-linked glycans; which… read more here.
Keywords: host fungus; linked glycans; sporothrix schenckii; interaction ... See more keywords
Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00740
Abstract: Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains. These Fab glycans are acquired following introduction of N-glycosylation sites… read more here.
Keywords: antibody stability; linked glycans; fab glycans; antibody ... See more keywords