Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.002
Abstract: A series of twenty four hydroxy-trifluoromethylpyrazoline-carbonyl-1,2,3-triazoles and four hydrazones bearing benzenesulfonamide moieties was obtained by condensation of carboxyhydrazides with substituted 1,3-diketones. All the newly synthesized compounds were investigated as inhibitors of physiologically and pharmacologically relevant… read more here.
Keywords: synthesis novel; benzenesulfonamide bearing; triazole linked; linked hydroxy ... See more keywords
N-Methylene-C Linked 4-Hydroxy-3,5-dinitropyrazole and N-Hydroxytetrazole: Insensitive Energetic Materials Enlivened by N-Hydroxyl Group.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c03763
Abstract: Optimization of oxygen balance without jeopardizing stability is one of the key objectives in synthesizing nitrogen-rich high-performing energetic materials. In this regard, choosing scaffolds with good nitrogen and oxygen content, along with the possibility of… read more here.
Keywords: energetic materials; methylene linked; insensitive energetic; hydroxytetrazole ... See more keywords