Articles with "linked kinase" as a keyword



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Integrin-Linked Kinase Activation Prevents Ventricular Arrhythmias Induced by Ischemia/Reperfusion Via Inhibition of Connexin 43 Remodeling

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Published in 2020 at "Journal of Cardiovascular Translational Research"

DOI: 10.1007/s12265-020-09979-2

Abstract: Ischemia reperfusion (I/R)-induced arrhythmia is a serious complication in patients with cardiac infarction. Remodeling of connexin (Cx) 43, manifested as phosphorylation, contributes significantly to arrhythmogenesis. Integrin-linked kinase (ILK) attenuated ventricular remodeling and improved cardiac function… read more here.

Keywords: integrin linked; ventricular arrhythmias; linked kinase; activation ... See more keywords
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Integrin linked kinase regulates endosomal recycling of N-cadherin in melanoma cells.

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Published in 2020 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2020.109642

Abstract: Malignant transformation is characterized by a phenotype "switch" from E- to N-cadherin - a major hallmark of epithelial to mesenchymal transition (EMT). The increased expression of N-cadherin is commonly followed by a growing capacity for… read more here.

Keywords: melanoma; integrin linked; ilk; expression ... See more keywords
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Integrin-linked kinase: A new actor in the ageing process?

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Published in 2017 at "Experimental Gerontology"

DOI: 10.1016/j.exger.2017.10.026

Abstract: Abstract Integrin‐linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated… read more here.

Keywords: senescence; integrin; integrin linked; ilk ... See more keywords
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Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

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Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-13220-3

Abstract: Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective retinal angiogenesis and associated complications that can result in vision loss. Defective Wnt/β-catenin signaling is an established cause of FEVR, whereas other molecular alterations… read more here.

Keywords: exudative vitreoretinopathy; linked kinase; integrin linked; retinal angiogenesis ... See more keywords
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Binding mechanism of caffeic acid and simvastatin to the integrin linked kinase for therapeutic implications: a comparative docking and MD simulation studies

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Published in 2018 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2018.1546621

Abstract: Abstract Integrin linked kinase (ILK) is a Ser/Thr kinase, which regulates various integrin mediated signaling pathways, and is involved in cell adhesion, migration and differentiation. Alteration in the ILK is responsible for abnormal functioning of… read more here.

Keywords: caffeic acid; mechanism; simvastatin; integrin linked ... See more keywords
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Abstract 5808: Integrin-linked kinase regulates Wnt transcriptional activity in platinum resistant ovarian cancer stem cells

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Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-5808

Abstract: Ovarian cancer (OC) is the most lethal gynecological cancer, characterized by chemo-resistance and fatal tumor recurrence after primary treatment. The metastatic progression is mediated by exfoliation of tumor cells into the peritoneal cavity, the formation… read more here.

Keywords: ovarian cancer; ilk; integrin linked; linked kinase ... See more keywords
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Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication

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Published in 2023 at "PLOS Pathogens"

DOI: 10.1371/journal.ppat.1011241

Abstract: Dengue virus (DENV) infection can induce life-threatening dengue hemorrhagic fever/dengue shock syndrome in infected patients. DENV is a threat to global health due to its growing numbers and incidence of infection in the last 50… read more here.

Keywords: denv infection; infection; integrin linked; linked kinase ... See more keywords