Synthesis of benzimidazole-linked-1,3,4-oxadiazole carboxamides as GSK-3β inhibitors with in vivo antidepressant activity.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.01.040
Abstract: Recent findings of potential implications of glycogen synthase kinase-3β (GSK-3β) dysfunction in psychiatric disorders like depression, have increased focus for development of GSK-3β inhibitors with possible anti-depressant activity. Keeping this in view, we synthesized a… read more here.
Keywords: oxadiazole carboxamides; linked oxadiazole; benzimidazole linked; vivo antidepressant ... See more keywords
New water-soluble isoxazole-linked 1,3,4-oxadiazole derivative with delocalized positive charge
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra05116d
Abstract: Herein we present a synthesis and characterization of a new water soluble isoxazole-linked 1,3,4-oxadiazole derivative owing the local positive charge at the carbon atom of oxadiazole moiety. read more here.
Keywords: linked oxadiazole; isoxazole linked; water soluble; soluble isoxazole ... See more keywords
Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123946
Abstract: To develop new compounds with high activity, broad spectrum and low-toxicity, 17 benzamides substituted with quinoline-linked 1,2,4-oxadiazole were designed using the splicing principle of active substructures and were synthesized. The biological activities were evaluated against… read more here.
Keywords: quinoline linked; linked oxadiazole; substituted quinoline; toxicity ... See more keywords