Emodin Inhibits AIM2 Inflammasome Activation via Modulating K27‐Linked Polyubiquitination to Attenuate Renal Fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8390
Abstract: Chronic kidney diseases (CKD) is a serious threat to people's health with renal fibrosis as the major pathological feature. The absent in melanoma 2 (AIM2) has recently been proposed to play a critical role in… read more here.
Keywords: emodin; fibrosis; renal fibrosis; aim2 inflammasome ... See more keywords
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23219-4
Abstract: Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the… read more here.
Keywords: antiviral immunity; linked polyubiquitination; k63 linked; mavs ... See more keywords
Ubc13-UEV mediated K63-linked polyubiquitination in plants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac239
Abstract: Ubiquitination is one of the best known post-translational modifications in eukaryotes, in which different linkage types of polyubiquitination result in different outputs of the target proteins. Distinct from the well-characterized K48-linked polyubiquitination that usually serves… read more here.
Keywords: linked polyubiquitination; polyubiquitination; ubc13 uev; uev mediated ... See more keywords
Duck MARCH8 Negatively Regulates the RLR Signaling Pathway through K29-Linked Polyubiquitination of MAVS.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200544
Abstract: Mitochondrial antiviral signaling protein (MAVS) is a key adaptor in cellular innate immunity. Ubiquitination plays an important role in regulating MAVS-mediated innate immune responses; however, the molecular mechanisms underlying ubiquitination of MAVS have not been… read more here.
Keywords: signaling pathway; duck; k29 linked; mavs ... See more keywords
MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7-Triggered T Cell Homeostasis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of immunology"
DOI: 10.4049/jimmunol.2400253
Abstract: IL-7 is a cytokine produced by stromal cells, which binds to IL-7Rα and plays an important role for homeostasis of T lymphocytes. Excessive activities of IL-7-triggered signaling pathways causes autoimmune diseases. How IL-7-triggered signaling and… read more here.
Keywords: polyubiquitination; homeostasis; triggered cell; linked polyubiquitination ... See more keywords