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Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2020.1761395
Abstract: Abstract A novel series of bis(1,4-dihydropyridine-3,5-dicarbonitrile) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine) derivatives which are linked to pyrazole units were prepared via Hantzsch like reaction of the bis-aldehydes with the respective 3-aminocrotonitrile and pyrazolone derivatives. Graphical Abstract
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Keywords:
linked pyrazole;
hantzsch synthesis;
pyrazole units;
synthesis bis ... See more keywords
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Published in 2022 at "Current drug discovery technologies"
DOI: 10.2174/1570163820666221125121625
Abstract: AIMS/BACKGROUND In the present study, a new series of 1,2,4-triazole linked to pyrazole derivatives (8a-j) of 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one were synthesized and assessed for their antibacterial and anticancer activity. OBJECTIVE Encouraged by these results, these analogues 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ones…
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Keywords:
synthesis biological;
activity evaluation;
biological activity;
activity ... See more keywords