NOVEL HYBRIDS OF QUINOLINE LINKED PYRIMIDINE DERIVATIVES AS CYCLOOXYGENASE INHIBITORS: MOLECULAR DOCKING, ADMET STUDY, AND MD SIMULATION
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2024v16i6.52023
Abstract: Objective: Finding novel anti-inflammatory compounds is a crucial sector of research despite the significant advances this field has made. Inefficiency and unfavorable side effects are indeed potential drawbacks of conventional therapy utilizing steroidal or nonsteroidal… read more here.
Keywords: linked pyrimidine; pyrimidine derivatives; quinoline linked; derivatives cyclooxygenase ... See more keywords
Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1390992
Abstract: Introduction Nuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-linked pyrimidines… read more here.
Keywords: linked pyrimidine; cancer; breast cancer; oxazine linked ... See more keywords