MRLR: unraveling high-resolution meiotic recombination by linked reads
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz503
Abstract: MOTIVATION Meiotic recombination facilitates the transmission of exchanged genetic material between homologous chromosomes and plays a crucial role in increasing the genetic variations in eukaryotic organisms. In humans, thousands of crossover events have been identified… read more here.
Keywords: resolution; high resolution; crossover events; linked reads ... See more keywords
Resolving the full spectrum of human genome variation using Linked-Reads.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.234443.118
Abstract: Large-scale population analyses coupled with advances in technology have demonstrated that the human genome is more diverse than originally thought. To date, this diversity has largely been uncovered using short-read whole-genome sequencing. However, these short-read… read more here.
Keywords: short read; resolving full; short reads; human genome ... See more keywords
Somatic variant analysis of linked-reads sequencing data with Lancet
Sign Up to like & getrecommendations! Published in 2019 at "F1000Research"
DOI: 10.7490/f1000research.1117597.1
Abstract: Summary: We present a new version of the popular somatic variant caller, Lancet, that supports the analysis of linked-reads sequencing data. By seamlessly integrating barcodes and haplotype read assignments within the colored De Bruijn graph… read more here.
Keywords: sequencing data; reads sequencing; lancet; somatic variant ... See more keywords