Optimization of Automated Synthesis of Amide-Linked RNA
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DOI: 10.1021/acsomega.2c02742
Abstract: The recent FDA approval of several antisense and siRNA drugs illustrates the utility of nucleic acid chemical modifications, but numerous challenges remain for generalized nucleic acid therapeutics, urging the exploration of new modification strategies. Replacing… read more here.
Keywords: synthesis; nucleic acid; amide linked; linked rna ... See more keywords
RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation
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DOI: 10.1038/s41598-019-42367-8
Abstract: Aberrant expression, dysfunction and particularly aggregation of a group of RNA-binding proteins, including TDP-43, FUS and RBM45, are associated with neurological disorders. These three disease-linked RNA-binding proteins all contain at least one RNA recognition motif… read more here.
Keywords: binding proteins; rna binding; disease; disease linked ... See more keywords