Novel Indole‐Linked 1,2,3‐Triazole Analogues: Synthesis, Anti‐Tubercular Screening, and Molecular Docking Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70083
Abstract: The design and synthesis of novel indole‐linked 1,2,3‐triazole hybrids targeting Mycobacterium tuberculosis (H37Rv). The methods are summarized, highlighting the use of CuAAC reactions for synthesis and characterization via HRMS, NMR, and in vitro anti‐tubercular screening. Key… read more here.
Keywords: molecular docking; linked triazole; anti tubercular; novel indole ... See more keywords
New acridine-9-carboxamide linked to 1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro, and in silico biological evaluations
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02603-7
Abstract: α-Glucosidase plays a major role in degradation of carbohydrates to glucose. Therefore, inhibition of this enzyme can be useful in the treatment of carbohydrate-related diseases such as diabetes, cancer, and viral infections. In this study,… read more here.
Keywords: linked triazole; compound; carboxamide linked; glucosidase ... See more keywords
Synthesis and In Vitro/In Silico α‑Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00387
Abstract: Type 2 diabetes mellitus is a chronic-metabolic disorder characterized by insulin resistance, resulting in persistent hyperglycemia and severe complications. α-Glucosidase inhibitors (AGIs) effectively control postprandial blood glucose level by delaying carbohydrate digestion. This study reports… read more here.
Keywords: linked triazole; glucosidase inhibitory; glucosidase; naphthalene linked ... See more keywords
Fluorescent 7-Azaindole N-linked 1,2,3-triazole: Synthesis and Study of Antimicrobial, Molecular Docking, ADME and DFT Properties
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj00223c
Abstract: Two libraries of biologically essential and fluorescent 7-azaindole N-linked benzyl 1,2,3-triazole (4a-4i) and 7-azaindole N-linked phenyl 1,2,3-triazole (4j-4q) hybrids have been designed and synthesized from N-propargyl 7-azaindole, i.e., 1-prop-2-ynyl-1H-pyrrolo[2,3-b]pyridine (2)... read more here.
Keywords: azaindole linked; linked triazole; triazole synthesis; synthesis study ... See more keywords
Discovery of Potent Anticancer Tricarboxamide Analogs Linked to 1,2,3-Triazole, Promoting EGFR and VEGFR Downregulation
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DOI: 10.1039/d5nj01143d
Abstract: This study reports the click synthesis of new sets of tricarboxamide and/or tricarboxylate-based 1,2,3-triazoles tethering various lipophilic and hypophilic side chains under optimized Cu(I)-Catalyzed Azide Alkyne Cycloaddition reaction (CuAAC). A... read more here.
Keywords: linked triazole; discovery potent; anticancer tricarboxamide; analogs linked ... See more keywords
Synthesis and Antitumor Activity of Erlotinib Derivatives Linked With 1,2,3-Triazole
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.793905
Abstract: Cervical cancer is one of the most important cause of cancer-related death and presents a major public health problem in many countries. To search for more novel antitumor agents against cervical cancer, 14 erlotinib-linked 1,2,3-triazole… read more here.
Keywords: cervical cancer; linked triazole; antitumor activity; antitumor ... See more keywords
Solid-Phase Synthesis Approaches and U-Rich RNA-Binding Activity of Homotrimer Nucleopeptide Containing Adenine Linked to L-azidohomoalanine Side Chain via 1,4-Linked-1,2,3-Triazole
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms262311687
Abstract: Nucleopeptides (NPs) are unnatural hybrid polymers designed by coupling nucleobases to the side chains of amino acid residues within peptides. In this study, we present the synthesis of an Fmoc-protected nucleobase amino acid (NBA) monomer… read more here.
Keywords: adenine; linked triazole; side; synthesis ... See more keywords
New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28030921
Abstract: The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays… read more here.
Keywords: linked triazole; based hybrids; hybrids linked; pyridine based ... See more keywords