New acridine-9-carboxamide linked to 1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro, and in silico biological evaluations
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DOI: 10.1007/s00044-020-02603-7
Abstract: α-Glucosidase plays a major role in degradation of carbohydrates to glucose. Therefore, inhibition of this enzyme can be useful in the treatment of carbohydrate-related diseases such as diabetes, cancer, and viral infections. In this study,… read more here.
Keywords: linked triazole; compound; carboxamide linked; glucosidase ... See more keywords
Fluorescent 7-Azaindole N-linked 1,2,3-triazole: Synthesis and Study of Antimicrobial, Molecular Docking, ADME and DFT Properties
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DOI: 10.1039/d3nj00223c
Abstract: Two libraries of biologically essential and fluorescent 7-azaindole N-linked benzyl 1,2,3-triazole (4a-4i) and 7-azaindole N-linked phenyl 1,2,3-triazole (4j-4q) hybrids have been designed and synthesized from N-propargyl 7-azaindole, i.e., 1-prop-2-ynyl-1H-pyrrolo[2,3-b]pyridine (2)... read more here.
Keywords: azaindole linked; linked triazole; triazole synthesis; synthesis study ... See more keywords
Synthesis and Antitumor Activity of Erlotinib Derivatives Linked With 1,2,3-Triazole
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DOI: 10.3389/fphar.2021.793905
Abstract: Cervical cancer is one of the most important cause of cancer-related death and presents a major public health problem in many countries. To search for more novel antitumor agents against cervical cancer, 14 erlotinib-linked 1,2,3-triazole… read more here.
Keywords: cervical cancer; linked triazole; antitumor activity; antitumor ... See more keywords
New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking
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DOI: 10.3390/molecules28030921
Abstract: The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays… read more here.
Keywords: linked triazole; based hybrids; hybrids linked; pyridine based ... See more keywords