K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response
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DOI: 10.1002/advs.202509817
Abstract: The ubiquitin chains perform diverse biological functions through different linkages. However, the understanding of non‐canonical K29‐linked ubiquitin chains is relatively limited. Exploring the physiological functions of K29‐linked ubiquitin chains beyond degradation is crucial for deciphering… read more here.
Keywords: k29 linked; cell proliferation; k29; linked ubiquitination ... See more keywords
K27‐linked noncanonic ubiquitination in immune regulation
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DOI: 10.1002/jlb.4ru0620-397rr
Abstract: Ubiquitination is a common form of posttranslational modification that has been implicated in regulating considerable immune signaling pathways. The functions of canonic K48‐ and K63‐linked ubiquitination have been well studied. However, the roles of noncanonic… read more here.
Keywords: noncanonic ubiquitination; k27 linked; linked ubiquitination; linked noncanonic ... See more keywords
Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis.
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DOI: 10.1016/j.celrep.2020.107990
Abstract: The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate immune responses against pathogens in macrophages. However, the role of YAP in macrophages during atherosclerosis and its mechanism of YAP activation remain unknown. Here, we… read more here.
Keywords: linked ubiquitination; yap promotes; macrophage k63; k63 linked ... See more keywords
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
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DOI: 10.1038/s41389-024-00517-2
Abstract: Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signaling pathways during carcinogenesis via ubiquitination. Tripartite-motif (TRIM) ubiquitin E3 ligases consist of over 70 members. However, the clinical… read more here.
Keywords: expression; linked ubiquitination; colorectal cancer; k63 linked ... See more keywords
DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer
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DOI: 10.1038/s41467-025-55851-9
Abstract: Hyperactivation of ribosome biogenesis (RiBi) drives cancer progression, yet the role of RiBi-associated proteins (RiBPs) in breast cancer (BC) is underexplored. In this study, we perform a comprehensive multi-omics analysis and reveal that assembly and… read more here.
Keywords: cancer; k63 linked; breast cancer; proliferation ... See more keywords
RNF123 Mediates Ubiquitination and Degradation of SOCS1 To Regulate Type I Interferon Production during Duck Tembusu Virus Infection
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DOI: 10.1128/jvi.00095-23
Abstract: In recent years, posttranslational modification (PTM) has gradually become a research hot spot in the field of innate immunity regulation, and ubiquitination is one of the critical PTMs. DTMUV has seriously endangered the development of… read more here.
Keywords: degradation socs1; k48 linked; infection; linked ubiquitination ... See more keywords