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   Articles with "linker" as a keyword



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Structural characterization of the linked NS2B‐NS3 protease of Zika virus

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recommendations! Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12741

Abstract: The Zika virus (ZIKV) NS2B‐NS3 protease is an important drug target. The conventional flaviviral protease constructs used for structural studies contain the NS2B cofactor region linked to the NS3 protease domain via a glycine‐rich flexible… read more here.

Keywords: ns3 protease; protease; ns2b ns3; linker ... See more keywords
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Tuning Hydrophilicity of Aluminum MOFs by a Mixed-Linker Strategy for Enhanced Performance in Water Adsorption-Driven Heat Allocation Application.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202301311

Abstract: Water adsorption-driven heat transfer (AHT) technology has emerged as a promising solution to address crisis of the global energy consumption and environmental pollution of current heating and cooling processes. Hydrophilicity of water adsorbents plays a… read more here.

Keywords: mofs; mixed linker; water; linker ... See more keywords

Novel benzenesulfonamide‐thiouracil conjugates with a flexible N‐ethyl acetamide linker as selective CA IX and CA XII inhibitors

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recommendations! Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200434

Abstract: Novel benzenesulfonamide derivatives linked to diverse functionalized thiouracils through a flexible N‐ethyl acetamide linker were designed and synthesized as carbonic anhydrase (CA) inhibitors. The synthesized candidates demonstrated a potent inhibitory activity against four different CA… read more here.

Keywords: novel benzenesulfonamide; xii; acetamide linker; linker ... See more keywords

Aromatic linker variations in novel dopamine D2 and D3 receptor ligands

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recommendations! Published in 2024 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202400071

Abstract: Dopamine D2‐like receptors, especially D2 and D3 receptor subtypes, are important targets of antipsychotic agents. Many of these antipsychotics share an aliphatic linker element between a protonable amine group and an acyl‐like moiety. Here, we… read more here.

Keywords: d2r d3r; dopamine receptor; linker; d3r ... See more keywords

Effect of linkers on immobilization of scFvs with biotin–streptavidin interaction

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recommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.1645

Abstract: Single‐chain variable fragment antibodies (scFvs) are attractive for use in applications that require high specificity and binding to a target, such as biosensors. Previously, we demonstrated that a variety of scFvs can be immobilized onto… read more here.

Keywords: linkers immobilization; biotin; linker; effect linkers ... See more keywords

Characterization of maltose‐binding protein–fused heparinases with enhanced thermostability by application of rigid and flexible linkers

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recommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.2642

Abstract: Heparinases, including heparinases I–III (HepI, HepII, and HepIII, respectively), are important tools for producing low‐molecular‐weight heparin, an improved anticoagulant. The poor thermostability of heparinases significantly hinders their industrial and laboratory applications. To improve the thermostability… read more here.

Keywords: thermostability; linker; binding protein; mbp fused ... See more keywords

New insights from modelling studies and molecular dynamics simulations of the DIS5-S6 extracellular linker of the skeletal muscle sodium channel NaV1.4.

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recommendations! Published in 2023 at "Biopolymers"

DOI: 10.1002/bip.23540

Abstract: In the CryoEM-structure of the hSkMNaV1.4 ion channel (PDB:6AGF), the 59-residue DIS5-S6 linker peptide was omitted due to absence of electron density. This peptide is intriguing - comprised of unique sequence and found only in… read more here.

Keywords: linker; muscle sodium; skeletal muscle; channel ... See more keywords

Molecular Cross‐Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700030

Abstract: Nonribosomal peptide synthetases (NRPSs) employ multiple domains separated by linker regions to incorporate substrates into natural products. During synthesis, substrates are covalently tethered to carrier proteins that translocate between catalytic partner domains. The molecular parameters… read more here.

Keywords: linker regions; carrier; linker; nonribosomal peptide ... See more keywords

Yeast Synthetic Terminators: Fine Regulation of Strength through Linker Sequences

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recommendations! Published in 2019 at "ChemBioChem"

DOI: 10.1002/cbic.201900163

Abstract: The design of improved synthetic components is an important research field in synthetic biology. The terminator, responsible for terminating gene transcription, is a necessary component for yeast gene expression. The efficiency element, the positioning element… read more here.

Keywords: strength; yeast synthetic; terminator; linker ... See more keywords

The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90

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recommendations! Published in 2020 at "Chembiochem"

DOI: 10.1002/cbic.202000699

Abstract: The molecular chaperone Hsp90 supports the functional activity of specific substrate proteins (clients). For client processing, the Hsp90 dimer undergoes a series of ATP‐driven conformational rearrangements. Flexible linkers connecting the three domains of Hsp90 are… read more here.

Keywords: modulates conformations; linker modulates; molecular interactions; linker ... See more keywords

Epitope Fine Mapping by Mass Spectrometry: Investigations of Immune Complexes Consisting of Monoclonal Anti‐HpTGEKP Antibody and Zinc Finger Protein Linker Phospho‐Hexapeptides

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200390

Abstract: Accurate formation of antibody‐antigen complexes has been relied on in both, multitudes of scientific projects and ample therapeutic and diagnostic applications. Mass spectrometrically determined dissociation behavior of immune complexes with the anti‐HpTGEKP antibody revealed that… read more here.

Keywords: immune complexes; linker; phospho; zinc finger ... See more keywords