Structural characterization of the linked NS2B‐NS3 protease of Zika virus
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12741
Abstract: The Zika virus (ZIKV) NS2B‐NS3 protease is an important drug target. The conventional flaviviral protease constructs used for structural studies contain the NS2B cofactor region linked to the NS3 protease domain via a glycine‐rich flexible… read more here.
Keywords: ns3 protease; protease; ns2b ns3; linker ... See more keywords
Tuning Hydrophilicity of Aluminum MOFs by a Mixed-Linker Strategy for Enhanced Performance in Water Adsorption-Driven Heat Allocation Application.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301311
Abstract: Water adsorption-driven heat transfer (AHT) technology has emerged as a promising solution to address crisis of the global energy consumption and environmental pollution of current heating and cooling processes. Hydrophilicity of water adsorbents plays a… read more here.
Keywords: mofs; mixed linker; water; linker ... See more keywords
Novel benzenesulfonamide‐thiouracil conjugates with a flexible N‐ethyl acetamide linker as selective CA IX and CA XII inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200434
Abstract: Novel benzenesulfonamide derivatives linked to diverse functionalized thiouracils through a flexible N‐ethyl acetamide linker were designed and synthesized as carbonic anhydrase (CA) inhibitors. The synthesized candidates demonstrated a potent inhibitory activity against four different CA… read more here.
Keywords: novel benzenesulfonamide; xii; acetamide linker; linker ... See more keywords
Effect of linkers on immobilization of scFvs with biotin–streptavidin interaction
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1645
Abstract: Single‐chain variable fragment antibodies (scFvs) are attractive for use in applications that require high specificity and binding to a target, such as biosensors. Previously, we demonstrated that a variety of scFvs can be immobilized onto… read more here.
Keywords: linkers immobilization; biotin; linker; effect linkers ... See more keywords
New insights from modelling studies and molecular dynamics simulations of the DIS5-S6 extracellular linker of the skeletal muscle sodium channel NaV1.4.
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23540
Abstract: In the CryoEM-structure of the hSkMNaV1.4 ion channel (PDB:6AGF), the 59-residue DIS5-S6 linker peptide was omitted due to absence of electron density. This peptide is intriguing - comprised of unique sequence and found only in… read more here.
Keywords: linker; muscle sodium; skeletal muscle; channel ... See more keywords
Molecular Cross‐Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700030
Abstract: Nonribosomal peptide synthetases (NRPSs) employ multiple domains separated by linker regions to incorporate substrates into natural products. During synthesis, substrates are covalently tethered to carrier proteins that translocate between catalytic partner domains. The molecular parameters… read more here.
Keywords: linker regions; carrier; linker; nonribosomal peptide ... See more keywords
Yeast Synthetic Terminators: Fine Regulation of Strength through Linker Sequences
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900163
Abstract: The design of improved synthetic components is an important research field in synthetic biology. The terminator, responsible for terminating gene transcription, is a necessary component for yeast gene expression. The efficiency element, the positioning element… read more here.
Keywords: strength; yeast synthetic; terminator; linker ... See more keywords
The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000699
Abstract: The molecular chaperone Hsp90 supports the functional activity of specific substrate proteins (clients). For client processing, the Hsp90 dimer undergoes a series of ATP‐driven conformational rearrangements. Flexible linkers connecting the three domains of Hsp90 are… read more here.
Keywords: modulates conformations; linker modulates; molecular interactions; linker ... See more keywords
Epitope Fine Mapping by Mass Spectrometry: Investigations of Immune Complexes Consisting of Monoclonal Anti‐HpTGEKP Antibody and Zinc Finger Protein Linker Phospho‐Hexapeptides
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200390
Abstract: Accurate formation of antibody‐antigen complexes has been relied on in both, multitudes of scientific projects and ample therapeutic and diagnostic applications. Mass spectrometrically determined dissociation behavior of immune complexes with the anti‐HpTGEKP antibody revealed that… read more here.
Keywords: immune complexes; linker; phospho; zinc finger ... See more keywords
Cleavable Linker Incorporation into a Synthetic Dye‐Nanobody‐Fluorescent Protein Assembly: FRET, FLIM and STED Microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200395
Abstract: A bright and photostable fluorescent dye with a disulfide (S−S) linker and maleimide group (Rho594‐S2‐mal), as cleavable and reactive sites, was synthesized and conjugated with anti‐GFP nanobodies (NB). The binding of EGFP (FRET donor) with… read more here.
Keywords: sted microscopy; microscopy; linker; dye ... See more keywords
Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria‐Targeted Triphenylphosphonium Constructs
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200774
Abstract: The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred‐fold within mitochondria in response to the mitochondrial membrane potential (Δψm).… read more here.
Keywords: mitochondria targeted; linker; enhance; within mitochondria ... See more keywords