Synthesis and Linker-Controlled Self-Assembly of Dendritic Amphiphiles with Branched Fluorinated Tails.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200108
Abstract: Amphiphiles containing fluorinated segments tend to aggregate in the aqueous solution into structure of lower curvature than their hydrocarbon analogues due to their larger diameter. A benefit of supramolecular structures incorporating fluorine moieties is their… read more here.
Keywords: controlled self; branched fluorinated; self assembly; linker controlled ... See more keywords
A click-ready pH-triggered phosphoramidate-based linker for controlled release of monomethyl auristatin E.
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron letters"
DOI: 10.1016/j.tetlet.2020.152398
Abstract: In this work, we developed a novel "click"-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at… read more here.
Keywords: controlled release; linker; release monomethyl; click ready ... See more keywords