Synthesis of MOFs for heterogeneous catalysis via linker design
Sign Up to like & getrecommendations! Published in 2018 at "Polyhedron"
DOI: 10.1016/j.poly.2018.07.021
Abstract: Abstract Metal–organic frameworks have been proved as ideal platforms for heterogeneous catalysis, and they have been utilized in a wide range of chemical reactions with promising catalytic performance. Due to the multicomponent nature of MOFs,… read more here.
Keywords: active sites; linker design; heterogeneous catalysis;
Deep Generative Models for 3D Linker Design
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.9b01120
Abstract: Rational compound design remains a challenging problem for both computational methods and medicinal chemists. Computational generative methods have begun to show promising results for the design problem. However, they have not yet used the power… read more here.
Keywords: linker design; information; design; generative models ... See more keywords
Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00482
Abstract: A current bottleneck in the development of proteolysis targeting chimeras (PROTACs) is the empirical nature of linker length structure-activity relationships (SARs). A multidisciplinary approach to alleviate the bottleneck is detailed here. First, we examine four… read more here.
Keywords: linker design; targeting chimeras; chemistry; proteolysis targeting ... See more keywords