Missing for partnership: understanding nucleosomal de novo DNA cytosine methylation by a spliced DNMT3 complex
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00461-2
Abstract: In a recent paper published in Nature, Xu et al. present a cryo-EM structure of a ‘spliced’ de novo DNA methyltransferase complex, DNMT3A2-DNMT3B3, bound to a mono-nucleosome with extended linker DNA. Reinforced by biochemical assays… read more here.
Keywords: methylation; dna; linker dna; novo dna ... See more keywords
A critical role for linker DNA in higher-order folding of chromatin fibers
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DOI: 10.1093/nar/gkab058
Abstract: Abstract Nucleosome-nucleosome interactions drive the folding of nucleosomal arrays into dense chromatin fibers. A better physical account of the folding of chromatin fibers is necessary to understand the role of chromatin in regulating DNA transactions.… read more here.
Keywords: dna; chromatin; chromatin fibers; linker dna ... See more keywords
Regulation of chromatin folding by conformational variations of nucleosome linker DNA
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx562
Abstract: Abstract Linker DNA conformational variability has been proposed to direct nucleosome array folding into more or less compact chromatin fibers but direct experimental evidence for such models are lacking. Here, we tested this hypothesis by… read more here.
Keywords: microscopy; dna; chromatin; linker dna ... See more keywords