The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166902
Abstract: Linker histones bind to nucleosomes and modify chromatin structure and dynamics as a means of epigenetic regulation. Biophysical studies have shown that chromatin fibers can adopt a plethora of conformations with varying levels of compaction.… read more here.
Keywords: fiber; linker; linker histone; structure ... See more keywords
Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing
Sign Up to like & getrecommendations! Published in 2019 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2018.07.002
Abstract: Linker histones are major players in chromatin organization and per se are essential players in genome homeostasis. As the fifth class of histone proteins the linker histones not only interact with DNA and core histones… read more here.
Keywords: linker histones; genome stability; linker; linker histone ... See more keywords
Interactome of Site-Specifically Acetylated Linker Histone H1.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00396
Abstract: Linker histone H1 plays a key role in chromatin organization and maintenance, yet our knowledge of the regulation of H1 functions by post-translational modifications is rather limited. In this study, we report on the generation… read more here.
Keywords: site specifically; interactome site; site; linker histone ... See more keywords
A Protein Semisynthesis-Based Strategy to Investigate the Functional Impact of Linker Histone Serine ADP-Ribosylation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00091
Abstract: Recently developed chemical and enzyme-based technologies to install serine ADP-ribosylation onto synthetic peptides have enabled new approaches to study poly(ADP-ribose) polymerase (PARP) biology. Here, we establish a generalizable strategy to prepare ADP-ribosylated peptides that are… read more here.
Keywords: adp ribosylation; ribosylation; linker histone; biology ... See more keywords
Elucidating the influence of linker histone variants on chromatosome dynamics and energetics
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa121
Abstract: Abstract Linker histones are epigenetic regulators that bind to nucleosomes and alter chromatin structures and dynamics. Biophysical studies have revealed two binding modes in the linker histone/nucleosome complex, the chromatosome, where the linker histone is… read more here.
Keywords: histone variants; linker; linker histone; elucidating influence ... See more keywords
Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac450
Abstract: Abstract Human Positive Coactivator 4 (PC4) is a multifaceted chromatin protein involved in diverse cellular processes including genome organization, transcription regulation, replication, DNA repair and autophagy. PC4 exists as a phospho-protein in cells which impinges… read more here.
Keywords: histone; transcription; pc4; linker histone ... See more keywords
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac716
Abstract: Abstract Post-translational modifications (PTMs) of core histones are important epigenetic determinants that correlate with functional chromatin states. However, despite multiple linker histone H1s PTMs have been identified, little is known about their genomic distribution and… read more here.
Keywords: h3k9 methylation; methylation; heterochromatin organization; linker histone ... See more keywords
Sensitive effect of linker histone binding mode and subtype on chromatin condensation
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz234
Abstract: Abstract The complex role of linker histone (LH) on chromatin compaction regulation has been highlighted by recent discoveries of the effect of LH binding variability and isoforms on genome structure and function. Here we examine… read more here.
Keywords: chromatin; effect; linker histone; binding mode ... See more keywords
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo
Sign Up to like & getrecommendations! Published in 2021 at "Open Biology"
DOI: 10.1098/rsob.200408
Abstract: Linker histones H1 are essential chromatin components that exist as multiple developmentally regulated variants. In metazoans, specific H1s are expressed during germline development in a tightly regulated manner. However, the mechanisms governing their stage-dependent expression… read more here.
Keywords: female germline; dbigh1; tumour suppressor; linker histone ... See more keywords
Involvement of the Linker Histone H1Foo in the Regulation of Oogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0233
Abstract: During oogenesis, oocytes show a unique mode of division and gene expression patterns. Chromatin structure is thought to be involved in the regulation of these processes. In this study, we investigated the functions of linker… read more here.
Keywords: h1foo; linker; oogenesis; regulation ... See more keywords
Structural mechanism of TAF-Iβ chaperone function on linker histone H1.10.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.2139/ssrn.4106200
Abstract: Linker histone H1, facilitated by its chaperones, plays an essential role in regulating gene expression by maintaining chromatin's higher-order structure and epigenetic state. However, we know little about the structural mechanism of how the chaperones… read more here.
Keywords: linker; taf; structural mechanism; linker histone ... See more keywords